OLIVEIRA DA CRUZ, Jose Fernando; GOMIS-GONZALEZ, Maria; MALDONADO, Rafael; MARSICANO, Giovanni; OZAITA, Andres; BUSQUETS-GARCIA, Arnau

doi:10.21769/BioProtoc.3651

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OLIVEIRA DA CRUZ, Jose Fernando
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

GOMIS-GONZALEZ, Maria
Universitat Pompeu Fabra [Barcelona] [UPF]

MALDONADO, Rafael
Universitat Pompeu Fabra [Barcelona] [UPF]

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Bio-protocol. 2020-06-20, vol. 10, n° 12

Resumen en inglés

The novel object recognition (NOR) task is a behavioral test commonly used to evaluate episodic-like declarative memory and it relies on the innate tendency of rodents to explore novelty. Here we present a maze used to evaluate NOR memory in mice that reduces the time of the assay while improving reliability of the measurements by increasing the exploratory behavior. This memory test, being performed in a two-arms maze, is suitable for several strains of mice (including inbreed and outbreed) and does not require extended training sessions allowing an accurate temporal assessment of memory formation. This particular maze increases the mouse exploration time and reduces variability compared to other arenas used before to assess NOR. As both long- and short-term NOR memory can be easily and accurately quantified using this paradigm, this improved methodology can be easily applied to study pharmacological, genetic or age-related modulation of cognitive function. Copyright © 2020 The Authors; exclusive licensee Bio-protocol LLC.< Leer menos

Palabras clave en inglés

Novel Object recognition memory

Cognition

Mouse behavior

Memory task

Learning

Animal behavior

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182672

DOI

http://dx.doi.org/10.21769/BioProtoc.3651

Proyecto ANR

Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003

Centros de investigación

Neurocentre Magendie - U1215