dc.rights.license | open | en_US |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | LEVY, Anna | |
hal.structure.identifier | Imaging, Brain & Neuropsychiatry [iBraiN] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | EL-HAGE, Wissam | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Laboratoires de neurosciences intégratives et cliniques (EA 481) | |
dc.contributor.author | BENNABI, Djamila | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux [NPsy-Sydo] | |
dc.contributor.author | ALLAUZE, Etienne | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BOUVARD, Alexandra | |
hal.structure.identifier | Imaging, Brain & Neuropsychiatry [iBraiN] | |
dc.contributor.author | CAMUS, Vincent | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | COURTET, Philippe | |
hal.structure.identifier | Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL] | |
dc.contributor.author | DOREY, Jean-Michel | |
dc.contributor.author | ETAIN, Bruno | |
dc.contributor.author | FOND, Guillaume | |
dc.contributor.author | GENTY, Jean-Baptiste | |
dc.contributor.author | HOLTZMANN, Jerome | |
dc.contributor.author | HORN, Mathilde | |
hal.structure.identifier | Institut Mondor de Recherche Biomédicale [IMRB] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | LEBOYER, Marion | |
dc.contributor.author | LLORCA, Pierre-Michel | |
dc.contributor.author | MEYREL, Manon | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | MOLIERE, Fanny | |
dc.contributor.author | NGUON, Anne-Sophie | |
dc.contributor.author | PETRUCCI, Jean | |
dc.contributor.author | REY, Romain | |
dc.contributor.author | RICHIERI, Raphaelle | |
dc.contributor.author | STEPHAN, Florian | |
dc.contributor.author | VAIVA, Guillaume | |
dc.contributor.author | WALTER, Michel | |
dc.contributor.author | HAFFEN, Emmanuel | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | AOUIZERATE, Bruno | |
dc.contributor.author | YRONDI, Antoine | |
dc.date.accessioned | 2023-06-12T09:29:25Z | |
dc.date.available | 2023-06-12T09:29:25Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1664-0640 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182644 | |
dc.description.abstractEn | Introduction: Treatment-resistant depression (TRD) is a disabling psychiatric condition characterized by the failure of two antidepressants (ADs). Since the occurrence of side effects (SEs) appears to be one of the main determinants of early discontinuation of pharmacological treatments contributing to a pseudo-resistance, the purpose of this study was to determine the parameters associated with the occurrence of SEs under ADs in a cohort of patients with TRD.Methods: An observational, cross-sectional, multicentre study was carried out using data from the French network of Expert Centers for TRD. For the 108 patients enrolled in the study, the statistical analyses focused on the overall occurrence and on the profile of the SEs (9 categories, 32 items).Results: SEs were influenced by age and sex and were positively associated with the intensity of anxious, depressive and suicidal symptoms, a history of childhood trauma (sexual abuse, emotional abuse and neglect), and negatively associated with self-esteem, and assessment of overall functioning.Conclusion: Using variables accessible in common practice, these results fall within the dynamic of a more tailored approach to medicine that could allow, through integrated pharmacological management, the continuation of antidepressant treatments, and therefore limit the risk of therapeutic failure. | |
dc.description.sponsorship | Sorbonne Universités à Paris pour l'Enseignement et la Recherche | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | Expert centres | |
dc.subject.en | Treatment-resistant depression | |
dc.subject.en | Antidepressants | |
dc.subject.en | Side effects | |
dc.subject.en | Clinical severity | |
dc.subject.en | Childhood trauma | |
dc.title.en | Occurrence of Side Effects in Treatment-Resistant Depression: Role of Clinical, Socio-Demographic and Environmental Characteristics | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.3389/fpsyt.2021.795666 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 34938218 | en_US |
bordeaux.journal | Frontiers in Psychiatry | en_US |
bordeaux.volume | 12 | en_US |
bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Fondation FondaMental | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
bordeaux.identifier.funderID | AstraZeneca | en_US |
hal.export | false | |
dc.rights.cc | CC BY | en_US |
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