Slow growing behavior in African trypanosomes during adipose tissue colonization
| dc.rights.license | open | en_US |
| dc.contributor.author | TRINDADE, Sandra | |
| dc.contributor.author | DE NIZ, Mariana | |
| dc.contributor.author | COSTA-SEQUEIRA, Mariana | |
| dc.contributor.author | BIZARRA-REBELO, Tiago | |
| dc.contributor.author | BENTO, Fábio | |
| dc.contributor.author | DEJUNG, Mario | |
| dc.contributor.author | NARCISO, Marta Valido | |
| dc.contributor.author | LÓPEZ-ESCOBAR, Lara | |
| dc.contributor.author | FERREIRA, João | |
| dc.contributor.author | BUTTER, Falk | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BRINGAUD, Frederic | |
| dc.contributor.author | GJINI, Erida | |
| dc.contributor.author | FIGUEIREDO, Luisa | |
| dc.date.accessioned | 2023-05-17T07:28:35Z | |
| dc.date.available | 2023-05-17T07:28:35Z | |
| dc.date.issued | 2022 | |
| dc.identifier.issn | 2041-1723 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182174 | |
| dc.description.abstractEn | Abstract When Trypanosoma brucei parasites, the causative agent of sleeping sickness, colonize the adipose tissue, they rewire gene expression. Whether this adaptation affects population behavior and disease treatment remained unknown. By using a mathematical model, we estimate that the population of adipose tissue forms (ATFs) proliferates slower than blood parasites. Analysis of the ATFs proteome, measurement of protein synthesis and proliferation rates confirm that the ATFs divide on average every 12 h, instead of 6 h in the blood. Importantly, the population of ATFs is heterogeneous with parasites doubling times ranging between 5 h and 35 h. Slow-proliferating parasites remain capable of reverting to the fast proliferation profile in blood conditions. Intravital imaging shows that ATFs are refractory to drug treatment. We propose that in adipose tissue, a subpopulation of T. brucei parasites acquire a slow growing behavior, which contributes to disease chronicity and treatment failure. | |
| dc.description.sponsorship | Alliance française contre les maladies parasitaires | en_US |
| dc.description.sponsorship | Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Slow growing behavior in African trypanosomes during adipose tissue colonization | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41467-022-34622-w | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN] | en_US |
| bordeaux.journal | Nature Communications | en_US |
| bordeaux.page | 7548 | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03921010 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2022&rft.volume=13&rft.issue=1&rft.spage=7548&rft.epage=7548&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=TRINDADE,%20Sandra&DE%20NIZ,%20Mariana&COSTA-SEQUEIRA,%20Mariana&BIZARRA-REBELO,%20Tiago&BENTO,%20F%C3%A1bio&rft.genre=article |
