LARNAUDIE, Sophie; PEYRET, Ariane; BEAUTÉ, Louis; NASSOY, Pierre; LECOMMANDOUX, Sébastien

doi:10.1021/acs.langmuir.9b01463

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LARNAUDIE, Sophie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

PEYRET, Ariane
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

BEAUTÉ, Louis
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Langmuir. 2019, vol. 35, n° 25, p. 8398-8403

American Chemical Society

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Poly(butadiene)-b-poly(ethylene oxide) (PBut2.5-b-PEO1.3) giant polymersomes were prepared using an emulsion-centrifugation method. The impact of a fast decrease of the osmotic pressure inside the lumen of giant PBut-b-PEO vesicles was studied by confocal microscopy. This osmotic imbalance was created by performing the photo-induced polymerization of acrylamide inside these giant polymersomes, mimicking cell-like confinement. Experimental conditions (irradiation time, relative concentration of monomer and photo-initiator) were optimized to induce the fastest and highest osmotic pressure difference in bulk solution. When confined inside polymersomes with low permeability membrane made of PBut-b-PEO copolymers, this hyper-osmotic shock induced a fast disruption of the membrane and polymersome burst. These findings, complementary to hypo-osmotic shock approaches previously reported, are demonstrating the versatility and relevance of controlling and modulating osmotic pressure imbalance in self-assembled artificial cell systems and protocells.< Réduire

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Photo-polymerization induced polymersome rupture

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