Stressing caveolae new role in cell mechanics
Idioma
en
Article de revue
Este ítem está publicado en
Trends in Cell Biology. 2012-07-01, vol. 22, n° 7, p. 381-389
Elsevier
Resumen en inglés
It has been almost 60 years since caveolae were first visualized by Eichi Yamada and George Palade. Nevertheless, these specialized invaginations of the plasma membrane remain without clear and recognized physiological ...Leer más >
It has been almost 60 years since caveolae were first visualized by Eichi Yamada and George Palade. Nevertheless, these specialized invaginations of the plasma membrane remain without clear and recognized physiological function. The recent identification of new caveolar components and the ability to probe cell mechanics with sophisticated opticophysical devices have shed new light on this fascinating organelle. Early studies from the 1970s suggested that caveolae could participate in the regulation of membrane dynamics. Recent data have established caveolae as mechanosensors that respond immediately to mechanical stress by flattening into the plasma membrane. Here, we focus on the molecular consequences that result from the caveolar disassembly/reassembly cycle induced by membrane tension variations at the surface of the cell under physiological and pathological conditions.< Leer menos
Palabras clave en inglés
TRANSCRIPT RELEASE FACTOR
NITRIC-OXIDE SYNTHASE
MEMBRANE TENSION
SIGNAL-TRANSDUCTION
PLASMA-MEMBRANE
SMOOTH-MUSCLE
POLYMERASE-I
GENERALIZED LIPODYSTROPHY
MUSCULAR-DYSTROPHY
ENDOTHELIAL-CELLS
Orígen
Importado de HalCentros de investigación