RIVIERE, Etienne; THIEBAUT, Rodolphe; LAZARO, Estibaliz; GUY, Alexandre; JAMES, Chloe; MANSIER, Olivier; BLANCO, Patrick; VIALLARD, Jean-Francois

doi:10.1111/bjh.18818

RIVIERE, Etienne
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases

THIEBAUT, Rodolphe

Bordeaux population health [BPH]

LAZARO, Estibaliz

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Article de revue

Ce document a été publié dans

British Journal of Haematology. 2023-04-20

Résumé en anglais

Immune thrombocytopenia (ITP) is defined by a low platelet count that can trigger potentially life-threatening haemorrhages. Three-quarters of adult patients exhibit persistent or chronic disease and require second-line treatments. Among these, rituximab, an anti-CD20 antibody, has yielded valuable results, with global responses in 60% of patients at 6 months and complete responses in 30% at 5 years. Factors predictive of response to ITP therapy would help physicians choose optimal treatments. We retrospectively analysed clinical courses, biological markers and blood lymphocyte subset numbers of 72 patients on rituximab to treat persistent/chronic ITP followed-up in our department between 2007 and 2021, divided into three groups according to the platelet count at 6 months: complete, partial or no response. Among all studied parameters, a low number of CD3 CD16 CD56 circulating NK cells was associated with the complete response to rituximab. We also found that, after rituximab therapy, complete responders exhibited increased NK and decreased activated CD8 T cell percentages. These results emphasize that the role played by NK cells in ITP remains incompletely known but that factors predictive of response to rituximab can be easily derived using blood lymphocyte subset data.< Réduire

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Article clinique

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https://oskar-bordeaux.fr/handle/20.500.12278/180989

DOI

http://dx.doi.org/10.1111/bjh.18818

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Assessment of circulating blood lymphocytes in adult patients on rituximab to treat immune thrombocytopenia: Circulating number of NK cells is associated with the response at 6 months.

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Licence d’utilisation du document

Assessment of circulating blood lymphocytes in adult patients on rituximab to treat immune thrombocytopenia: Circulating number of NK cells is associated with the response at 6 months.

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés

URI

DOI

Unités de recherche