COMBES, Denis; SILLAR, Keith T.; SIMMERS, John

doi:10.2741/s338

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

SILLAR, Keith T.

SIMMERS, John

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

Langue

Article de revue

Ce document a été publié dans

Frontiers in Bioscience. 2012-06-01, vol. S4, n° 4, p. 1364–1374

Résumé en anglais

In the South African clawed frog, Xenopus laevis, a complete functional switch in the mode of locomotion occurs during development from axial, undulatory, tail-based swimming in post-hatching tadpoles to limb-based kick propulsion in the adult froglet. At key stages during the metamorphosis from tadpole to frog both locomotor systems are present, co-functional and subject to modulation by the two ubiquitous biogenic amines, serotonin (5-HT) and noradrenaline (NA), arising from the brainstem. Here we review evidence on the roles of 5-HT and NA in the early maturation and dynamic modulation of spinal locomotor circuitry in the postembryonic tadpole and describe the way in which the modulatory effects of the two amines, which are always in opposition, subsequently switch during the metamorphic period of development. We speculate on the underlying cellular, synaptic and network mechanisms that might be responsible for this change in role.< Réduire

Mots clés en anglais

Locomotion

Swimming

CPG

Neural circuit

Development

Metamorphosis

Modulation

Biogenic amine

Amphibian

Xenopus

Review

URI

https://oskar-bordeaux.fr/handle/20.500.12278/173245

DOI

http://dx.doi.org/10.2741/s338

Project ANR

Quand la moelle épinière parle aux yeux – bases neuronales et plasticité développementale d'un nouveau mécanisme d'ajustement du regard pendant la locomotion des vertébrés - ANR-08-BLAN-0145

Unités de recherche

Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287

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A switch in aminergic modulation of locomotor CPG output during amphibian metamorphosis