Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in inflammatory bowel diseases
| dc.rights.license | open | en_US |
| dc.contributor.author | MICHAUD, Eva | |
| dc.contributor.author | WAECKEL, Louis | |
| dc.contributor.author | GAYET, Remi | |
| dc.contributor.author | GOGUYER-DESCHAUMES, Roman | |
| dc.contributor.author | CHANUT, Blandine | |
| dc.contributor.author | JOSPIN, Fabienne | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BATHANY, Katell | |
| dc.contributor.author | MONNOYE, Magali | |
| dc.contributor.author | GENET, Coraline | |
| dc.contributor.author | PRIER, Amelie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | TOKARSKI, Caroline | |
| dc.contributor.author | GÉRARD, Philippe | |
| dc.contributor.author | ROBLIN, Xavier | |
| dc.contributor.author | ROCHEREAU, Nicolas | |
| dc.contributor.author | PAUL, Stephane | |
| dc.date.accessioned | 2023-04-26T12:29:29Z | |
| dc.date.available | 2023-04-26T12:29:29Z | |
| dc.date.issued | 2022-08-08 | |
| dc.identifier.issn | 1757-4676 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/173214 | |
| dc.description.abstractEn | Abstract Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota requires broad affinity IgA and glycan?glycan interaction. Here, we asked whether IgA1 and IgA2-microbiota interactions might be involved in dysbiosis induction during inflammatory bowel diseases. Using stool HPLC-purified IgA, we show that reverse-transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA-bound microbiota in CD and UC showed distinct IgA1- and IgA2-associated microbiota; the IgA1+ fraction of CD microbiota was notably enriched in beneficial commensals. These features were associated with increased IgA anti-glycan reactivity in CD and an opposite loss of reactivity in UC. Our results highlight previously unknown pathogenic properties of IgA in IBD that could support dysbiosis. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | SIgA | |
| dc.subject.en | Microbiota | |
| dc.subject.en | Glycosylation | |
| dc.subject.en | IBD | |
| dc.subject.en | Immunity | |
| dc.title.en | Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in inflammatory bowel diseases | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.15252/emmm.202115386 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | EMBO Molecular Medicine | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EMBO%20Molecular%20Medicine&rft.date=2022-08-08&rft.volume=14&rft.issue=8&rft.eissn=1757-4676&rft.issn=1757-4676&rft.au=MICHAUD,%20Eva&WAECKEL,%20Louis&GAYET,%20Remi&GOGUYER-DESCHAUMES,%20Roman&CHANUT,%20Blandine&rft.genre=article |
