BAKHIT, Yousuf; SCHMITT, Ina; HAMED, Ahlam; IBRAHIM, Etedal Ahmed A.; MOHAMED, Inaam N.; EL-SADIG, Sarah M.; ELSEED, Maha A.; ALEBEED, Mohamed A.; SHAHEEN, Mutaz T.; IBRAHIM, Mohamed O.; ELHASSAN, Ali A.; ELTOM, Khalid; ALI, Hiba A.; IBRAHIM, Yousuf A.; ALMAK, Murad E.; ABUBAKER, Rayan; AHMED, Mohamed Anwer; ABUGRAIN, Ahmed A.; ELRASHEED, Salma M.; OMAR, Mawia A.; ALMAHAL, Mohamed A.; MOHAMEDSHARIF, Abubaker A.; TAHIR, Mohamed Y.; MALIK, Sawazen M.; ELDIRDIRI, Hazim S.; KHIDIR, Reem J.; MOHAMED, Malaz T.; ABDALLA, Abdelmohaymin; OMER, Farouk Yassen; ELSAYED, Liena E.O.; BABIKIR, Haydar El Hadi; BUKHARI, Elfateh Abd-Allah; SEIDI, Osheik; WÜLLNER, Ullrich

doi:10.1016/j.parkreldis.2022.05.009

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

Idioma

Article de revue

Este ítem está publicado en

Parkinsonism and Related Disorders. 2022-08, vol. 101, p. 6-8

Resumen en inglés

Background: Several studies suggested a significant role of epigenetic changes, including alterations in miRNA, histone modifications, and DNA methylation of α-synuclein (SNCA) in Parkinson’s disease (PD) pathogenicity. As of yet, only very few studies have been carried out in this field in Africa and none in Sudan. Materials and methods: We collected DNA from 172 Sudanese individuals (90 cases, 82 controls) who donated saliva for DNA extraction (mean age of onset: 40.6 ± 22.4 years). A family history of PD was evident in 64 patients. DNA preparation and bisulfite sequencing of SNCAintron1 was performed as described earlier. Results: Of the fourteen analyzed CpGs of SNCAintron1, CpGs 16-23 were hypomethylated in PD (P-value ranged from 0.023 to 0.003). P–values improved, when sporadic cases were excluded from the analysis. Conclusion: We identified the presence of a specific pattern of DNA methylation in a young Sudanese cohort of familial PD, which confirms the importance of the methylation of SNCAintron1 for PD. This phenomenon appears to be independent of ethnicity, the impact of environmental factors, drug history, or familial clustering.< Leer menos

Palabras clave en inglés

Parkinson’s disease

Methylation

Sudan

SNCA

Metadatos

Compartir este ítem

Licencia de uso del documento

Methylation of alpha-synuclein in a Sudanese cohort

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación

Publicaciones correspondientes

Sin título ﻿

Structure and luminescence properties of silver-doped NaY(PO3)4 crystal ﻿

Synthesis, crystal structure and vibrational spectra characterization of MILa(PO3)4 (MI = Na, Ag) ﻿

Sin título

Structure and luminescence properties of silver-doped NaY(PO3)4 crystal

Synthesis, crystal structure and vibrational spectra characterization of MILa(PO3)4 (MI = Na, Ag)