Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | PASSIEUX, Renaud | |
| dc.contributor.author | SUDRE, Guillaume | |
| dc.contributor.author | MONTEMBAULT, Alexandra | |
| dc.contributor.author | RENARD, Martine | |
| dc.contributor.author | HAGEGE, Agnes | |
| dc.contributor.author | ALCOUFFE, Pierre | |
| dc.contributor.author | HADDANE, Ali | |
| dc.contributor.author | VANDESTEENE, Marie | |
| dc.contributor.author | BOUCARD, Nadege | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | BORDENAVE, Laurence | |
| dc.contributor.author | DAVID, Laurent | |
| dc.date.accessioned | 2023-03-30T12:16:44Z | |
| dc.date.available | 2023-03-30T12:16:44Z | |
| dc.date.issued | 2022-04-11 | |
| dc.identifier.issn | 1735-1748 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172664 | |
| dc.description.abstractEn | The wet spinning of cytocompatible, bioresorbable, and knittable chitosan (CTS) monofilaments would be advantageous for a variety of surgical applications. The complexation capacity of chitosan with Cu2+ or Zn2+ can be leveraged to enhance its antibacterial activity, but not at the expense of cytocompatibility. In this work, a wet-spinning process was adapted for the in situ incorporation of Cu2+ or Zn2+ with chitosan dopes to produce monofilaments at different drawing ratios (τtot) with various cation/glucosamine molar ratios, evaluated in the fibers (rCu,f and rZn,f). Cytocompatibility and antibacterial activity of wet-spun monofilaments were, respectively, quantified by in vitro live-dead assays on balb 3T3 and by different evaluations of the proliferation inhibition of Staphylococcus epidermidis (Gram+) and Escherichia coli (Gram−). Knittability was tested by a specific tensile test using a knitting needle and evaluated with an industrial knitting machine. It was found that rCu,f = 0.01 and rZn,f = 0.03 significantly increase the antibacterial activity without compromising cytocompatibility. Wet spinning with τtot = 1.6 allowed the production of knittable CTS-Cu monofilaments, as confirmed by knitting assays under industrial conditions. | |
| dc.description.sponsorship | Lignes synchrotron françaises à l'ESRF - ANR-11-EQPX-0010 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | chitosan | |
| dc.subject.en | wet-spinning | |
| dc.subject.en | knittability | |
| dc.subject.en | complexation | |
| dc.subject.en | antibacterial | |
| dc.subject.en | cytocompatibility | |
| dc.title.en | Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+ | |
| dc.title.alternative | ACS Biomater. Sci. Eng. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1021/acsbiomaterials.2c00079 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| bordeaux.journal | Acs Biomaterials Science & Engineering | en_US |
| bordeaux.page | 1735-1748 | en_US |
| bordeaux.volume | 8 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.institution | Institut Bergonié | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acs%20Biomaterials%20Science%20&%20Engineering&rft.date=2022-04-11&rft.volume=8&rft.issue=4&rft.spage=1735-1748&rft.epage=1735-1748&rft.eissn=1735-1748&rft.issn=1735-1748&rft.au=PASSIEUX,%20Renaud&SUDRE,%20Guillaume&MONTEMBAULT,%20Alexandra&RENARD,%20Martine&HAGEGE,%20Agnes&rft.genre=article |
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