KOUBIYR, Ismail; BROEDERS, Tommy A.A; DELOIRE, Mathilde; BROCHET, Bruno; TOURDIAS, Thomas; GEURTS, Jeroen J.G.; SCHOONHEIM, Menno Michiel; RUET, Aurelie

doi:10.1177/13524585221101470

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

KOUBIYR, Ismail

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

BROEDERS, Tommy A.A
Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam

DELOIRE, Mathilde

Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]

Langue

Article de revue

Ce document a été publié dans

Multiple Sclerosis Journal. 2022-10, vol. 28, n° 12, p. 1973-1982

Résumé en anglais

Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline. © The Author(s), 2022.< Réduire

Mots clés en anglais

CIS

Multiple sclerosis

Cognition

Dynamic FC

fMRI

Longitudinal

Functional magnetic resonance imaging

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche