HEJBLUM, Boris; BA, Kalidou; THIEBAUT, Rodolphe; AGNIEL, Denis

doi:10.1101/2022.05.10.490529

Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]

BA, Kalidou
Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]

THIEBAUT, Rodolphe

Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]

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Document de travail - Pré-publication

Resumen en inglés

By reproducing differential expression analysis simulation results presented by Li et al , we identified a caveat in the data generation process. Data not truly generated under the null hypothesis led to incorrect comparisons of benchmark methods. We provide corrected simulation results that demonstrate the good performance of dearseq and argue against the superiority of the Wilcoxon rank-sum test as suggested by Li et al . Please see related Research article with DOI 10.1186/s13059-022-02648-4 .< Leer menos

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https://oskar-bordeaux.fr/handle/20.500.12278/172283

DOI

http://dx.doi.org/10.1101/2022.05.10.490529

Centros de investigación

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Neglecting normalization impact in semi-synthetic RNA-seq data simulation generates artificial false positives

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Resumen en inglés

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DOI

Centros de investigación