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dc.rights.licenseopenen_US
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorGRILLAULT LAROCHE, Diane
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierInstitut de Neurosciences de la Timone [INT]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierLaboratoire de psychologie [LabPsy]
dc.contributor.authorM BAILARA, Katia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLOFTUS, Josephine
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorDUBERTRET, Caroline
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLLORCA, Pierre-Michel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorOLIE, Emilie
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPASSERIEUX, Christine
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPOLOSAN, Mircea
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSCHWAN, Raymund
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorBELLIVIER, Frank
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorMARIE-CLAIRE, Cynthia
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorETAIN, Bruno
dc.date.accessioned2023-02-13T13:46:00Z
dc.date.available2023-02-13T13:46:00Z
dc.date.issued2022-01-26
dc.identifier.issn000-1690Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171937
dc.description.abstractEnObjectives: Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether childhood maltreatment may be associated with the time to recurrence in BD. Methods: Individuals with BD (N = 2008) were assessed clinically and for childhood maltreatment at baseline, and followed up for two years. The cumulative probability of mood recurrence over time was estimated with the Turnbull’s extension of the Kaplan–Meier analysis for interval-censored data, including childhood maltreatment as a whole, and then maltreatment subtypes as predictors. Analyses were adjusted for potential confounding factors. Results: The median duration of follow-up was 22.3 months (IQR:12.0–24.8). Univariable analyses showed associations between childhood maltreatment, in particular all types of abuses (emotional, physical, and sexual) or emotional neglect, and a shorter time to recurrence (all p < 0.001). When including potential confounders into the multivariable models, the time to mood recurrence was associated with multiple/severe childhood maltreatment (i.e., total score above the 75th percentile) (HR = 1.32 95%CI (1.11–1.57), p = 0.002), and more specifically with moderate/severe physical abuse (HR = 1.44 95%CI(1.21–1.73), p < 0.0001). Living alone, lifetime anxiety disorders, lifetime number of mood episodes, baseline depressive and (hypo)manic symptoms, and baseline use of atypical antipsychotics were also associated with the time to recurrence. Conclusions: In addition to typical predictors of mood recurrences, an exposure to multiple/severe forms of childhood maltreatment, and more specifically to moderate to severe physical abuse, may increase the risk for a mood recurrence in BD. This leads to the recommendations of more scrutiny and denser follow-up of the individuals having been exposed to such early-life stressors. © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.description.sponsorshipMicroARNs et réseaux de gènes co-exprimés associés aux traumatismes dans l'enfance: de la cicatrice moléculaire aux pistes thérapeutiques dans les troubles bipolaires - ANR-18-CE37-0002en_US
dc.language.isoENen_US
dc.subject.enBipolar disorders
dc.subject.enChildhood maltreatment
dc.subject.enChildhood trauma
dc.subject.enMood recurrence
dc.subject.enPhysical abuse
dc.subject.enSurvival analysess
dc.title.enAssociation between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/acps.13401en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35080248en_US
bordeaux.journalActa Psychiatrica Scandinavicaen_US
bordeaux.page373-383en_US
bordeaux.volume145en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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