ZHANG, Tingting; PERUCH, Frédéric; WEBER, Amélie; BATHANY, Katell; FAUQUIGNON, Martin; MUTSCHLER, Angela; SCHATZ, Christophe; GARBAY, Bertrand

doi:10.1039/d2ra06603c

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Team 1 LCPO : Polymerization Catalyses & Engineering

PERUCH, Frédéric

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering

WEBER, Amélie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Ce document a été publié dans

RSC Advances. 2023-01-12, vol. 13, n° 3, p. 2190

Résumé en anglais

Developing new biomaterials is an active research area owing to their applications in regenerative medicine, tissue engineering and drug delivery. Elastin-like polypeptides (ELPs) are good candidates for these applications because they are biosourced, biocompatible and biodegradable. With the aim of developing ELP-based micelles for drug delivery applications we have synthesized 15 acyl-ELP compounds by conjugating myristic, palmitic, stearic, oleic or linoleic acid to the N-terminus of three ELPs differing in molar mass. The ELP-fatty acid conjugates have interesting solution behavior. They form micelles at low temperatures and aggregate above the cloud point temperature (Tcp). The critical micelle concentration depends on the fatty acid nature while the micelle size is mainly determined by the ELP block length. We were able to show that ELPs were better hydrated in the micelles than in their individual state in solution. The micelles are stable in phosphate-buffer saline at temperatures below the Tcp, which can vary between 20 °C and 38 °C depending on the length or hydrophilicity of the ELP. Acyl-ELP micelles were loaded with the small hydrophobic molecule Nile red. The encapsulation efficiency and release kinetics showed that the best loading conditions were achieved with the largest ELP conjugated to stearic acid.< Réduire

Mots clés en anglais

Elastin-like polypeptides (ELPs)

Fatty acids

Star-like micelles

Self-assembly

Nile red encapsulation

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https://oskar-bordeaux.fr/handle/20.500.12278/171665

DOI

http://dx.doi.org/10.1039/d2ra06603c

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Solution behavior and encapsulation properties of fatty acid-elastin-like polypeptide conjugates

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Résumé en anglais

Mots clés en anglais

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DOI

Unités de recherche