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dc.rights.licenseopenen_US
dc.contributor.authorSOULAGES, Antoine
dc.contributor.authorMAISONOBE, Thierry
dc.contributor.authorAUZOU, Pascal
dc.contributor.authorPETIT, Antoine
dc.contributor.authorALLENBACH, Yves
dc.contributor.authorBARETE, Stephane
dc.contributor.authorSKOPINSKI, Sophie
dc.contributor.authorRIBEIRO, Emmanuel
dc.contributor.authorJULLIE, Marie-Laure
dc.contributor.authorLAMANT, Laurence
dc.contributor.authorBREVET, Françoise
dc.contributor.authorSOULAGES, Xavier
dc.contributor.authorVALLAT, Jean-Michel
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMARTIN-NEGRIER, Marie-Laure
dc.contributor.authorSOLE, Guillaume
dc.contributor.authorDUVAL, Fanny
dc.contributor.authorCARLA, Louis
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLE MASSON, Gwendal
dc.contributor.authorMATHIS, Stephane
dc.date.accessioned2023-01-03T14:50:42Z
dc.date.available2023-01-03T14:50:42Z
dc.date.issued2022-07
dc.identifier.issn0340-5354en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171597
dc.description.abstractEnBackground: Livedoid vasculopathy (LV) is a chronic dermatosis associated with micro-thrombosis of the vessels of the dermis, leading to ischemic lesions and painful skin ulcerations of the lower limbs. This thrombosing occlusive vasculopathy, clearly distinct from 'classical vasculitis' (not related to alteration of vessel walls), may lead to peripheral neuropathy. Objective: To clarify the main clinical, electrophysiological and pathological characteristics of peripheral neuropathy linked to LV. Method: We presented a series of personal cases of peripheral neuropathy due to LV. We also conducted a review of the literature (since the first description of LV in 1974) using multiple combinations of keywords from 'PubMed', 'Google Scholar' and 'ScienceDirect' databases according to the 'Preferred Reporting Items for Systematic reviews and Meta-Analyses' guidelines. Results: We identified 16 patients (6 personal cases and 10 cases from the medical literature). Our personal cases were five females and one male, with a median age (at the onset of cutaneous signs of LV) of 38 (range 25-62). Several types of skin lesions of the lower limbs were observed. Median age at the onset of peripheral neuropathy symptoms was 48 years (range 29-66), with a main clinical and electrophysiological pattern of mononeuropathy multiplex. Discussion: We observed a typical pattern of peripheral neuropathy, mostly mononeuropathy multiplex, whose pathophysiology might be related to occlusions of the small vessels of the nerves, as seen in the dermis. Moreover, LV may also be associated with other types of peripheral neuropathies (sometimes of autoimmune etiology) not directly related to the skin lesions. Conclusion: The 'ischemic form' of peripheral neuropathy linked to LV is mainly responsible for sensory disturbances (with multifocal distribution), sometimes for motor disturbances. This type of peripheral neuropathy has to be distinguished from 'classical vasculitic neuropathies' which are usually treated with antithrombotic therapies.
dc.language.isoENen_US
dc.subject.enLivedoid
dc.subject.enMononeuropathy
dc.subject.enPeripheral neuropathy
dc.subject.enVasculitis
dc.subject.enVasculopathy
dc.title.enPeripheral neuropathy and livedoid vasculopathy
dc.title.alternativeJ Neurolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00415-022-11007-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35166926en_US
bordeaux.journalJournal of Neurologyen_US
bordeaux.page3779-3788en_US
bordeaux.volume269en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionCNRS
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03832490
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Neurology&rft.date=2022-07&rft.volume=269&rft.issue=7&rft.spage=3779-3788&rft.epage=3779-3788&rft.eissn=0340-5354&rft.issn=0340-5354&rft.au=SOULAGES,%20Antoine&MAISONOBE,%20Thierry&AUZOU,%20Pascal&PETIT,%20Antoine&ALLENBACH,%20Yves&rft.genre=article


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