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dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorABY, Franck
dc.contributor.authorLORENZO, Louis-Etienne
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorGRIVET, Zoe
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBOUALI-BENAZZOUZ, Rabia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTIN, Hugo
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorVALERIO, Stephane
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorWHITESTONE, Sara
dc.contributor.authorISABEL, Dominique
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorIDI, Walid
dc.contributor.authorBOUCHATTA, Otmane
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDE DEURWAERDERE, Philippe
dc.contributor.authorGODIN, Antoine G.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHERRY, Cyril
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorLANDRY, Marc
dc.contributor.authorDE KONINCK, Yves
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorFOSSAT, Pascal
dc.date.accessioned2022-12-01T13:34:03Z
dc.date.available2022-12-01T13:34:03Z
dc.date.issued2022-07-29
dc.identifier.issn2375-2548en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170445
dc.description.abstractEnDescending control from the brain to the spinal cord shapes our pain experience, ranging from powerful analgesia to extreme sensitivity. Increasing evidence from both preclinical and clinical studies points to an imbalance toward descending facilitation as a substrate of pathological pain, but the underlying mechanisms remain unknown. We used an optogenetic approach to manipulate serotonin (5-HT) neurons of the nucleus raphe magnus that project to the dorsal horn of the spinal cord. We found that 5-HT neurons exert an analgesic action in naïve mice that becomes proalgesic in an experimental model of neuropathic pain. We show that spinal KCC2 hypofunction turns this descending inhibitory control into paradoxical facilitation; KCC2 enhancers restored 5-HT–mediated descending inhibition and analgesia. Last, combining selective serotonin reuptake inhibitors (SSRIs) with a KCC2 enhancer yields effective analgesia against nerve injury–induced pain hypersensitivity. This uncovers a previously unidentified therapeutic path for SSRIs against neuropathic pain. Copyright © 2022 The Authors.
dc.description.sponsorshipCircuits neuronaux de l'analgésie conditionnéeen_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enChlorine Compounds
dc.subject.enHealth
dc.subject.enClinical Study
dc.subject.enDescending Inhibitions
dc.subject.enExperimental Modelling
dc.subject.enNerve Injuries
dc.subject.enNeuropathic Pain
dc.subject.enOptogenetics
dc.subject.enPreclinical Studies
dc.subject.enSelective Serotonin Re-Uptake Inhibitors
dc.subject.enSpinal-Cord
dc.subject.enMammals
dc.title.enSwitch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
dc.title.alternativeSci Adven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1126/sciadv.abo0689en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35895817en_US
bordeaux.journalScience Advancesen_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue30en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionINRAE
bordeaux.teamCircuits neuronaux des apprentissages associatifsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDCanada Research Chairsen_US
bordeaux.identifier.funderIDCanadian Institutes of Health Researchen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2022-07-29&rft.volume=8&rft.issue=30&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=ABY,%20Franck&LORENZO,%20Louis-Etienne&GRIVET,%20Zoe&BOUALI-BENAZZOUZ,%20Rabia&MARTIN,%20Hugo&rft.genre=article


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