Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | ABY, Franck | |
| dc.contributor.author | LORENZO, Louis-Etienne | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | GRIVET, Zoe | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BOUALI-BENAZZOUZ, Rabia | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MARTIN, Hugo | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | VALERIO, Stephane | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | WHITESTONE, Sara | |
| dc.contributor.author | ISABEL, Dominique | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | IDI, Walid | |
| dc.contributor.author | BOUCHATTA, Otmane | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | DE DEURWAERDERE, Philippe | |
| dc.contributor.author | GODIN, Antoine G. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | HERRY, Cyril | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FIORAMONTI, Xavier | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | LANDRY, Marc | |
| dc.contributor.author | DE KONINCK, Yves | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | FOSSAT, Pascal | |
| dc.date.accessioned | 2022-12-01T13:34:03Z | |
| dc.date.available | 2022-12-01T13:34:03Z | |
| dc.date.issued | 2022-07-29 | |
| dc.identifier.issn | 2375-2548 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170445 | |
| dc.description.abstractEn | Descending control from the brain to the spinal cord shapes our pain experience, ranging from powerful analgesia to extreme sensitivity. Increasing evidence from both preclinical and clinical studies points to an imbalance toward descending facilitation as a substrate of pathological pain, but the underlying mechanisms remain unknown. We used an optogenetic approach to manipulate serotonin (5-HT) neurons of the nucleus raphe magnus that project to the dorsal horn of the spinal cord. We found that 5-HT neurons exert an analgesic action in naïve mice that becomes proalgesic in an experimental model of neuropathic pain. We show that spinal KCC2 hypofunction turns this descending inhibitory control into paradoxical facilitation; KCC2 enhancers restored 5-HT–mediated descending inhibition and analgesia. Last, combining selective serotonin reuptake inhibitors (SSRIs) with a KCC2 enhancer yields effective analgesia against nerve injury–induced pain hypersensitivity. This uncovers a previously unidentified therapeutic path for SSRIs against neuropathic pain. Copyright © 2022 The Authors. | |
| dc.description.sponsorship | Circuits neuronaux de l'analgésie conditionnée | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Chlorine Compounds | |
| dc.subject.en | Health | |
| dc.subject.en | Clinical Study | |
| dc.subject.en | Descending Inhibitions | |
| dc.subject.en | Experimental Modelling | |
| dc.subject.en | Nerve Injuries | |
| dc.subject.en | Neuropathic Pain | |
| dc.subject.en | Optogenetics | |
| dc.subject.en | Preclinical Studies | |
| dc.subject.en | Selective Serotonin Re-Uptake Inhibitors | |
| dc.subject.en | Spinal-Cord | |
| dc.subject.en | Mammals | |
| dc.title.en | Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain | |
| dc.title.alternative | Sci Adv | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1126/sciadv.abo0689 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35895817 | en_US |
| bordeaux.journal | Science Advances | en_US |
| bordeaux.volume | 8 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 30 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.institution | INRAE | |
| bordeaux.team | Circuits neuronaux des apprentissages associatifs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Canada Research Chairs | en_US |
| bordeaux.identifier.funderID | Canadian Institutes of Health Research | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2022-07-29&rft.volume=8&rft.issue=30&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=ABY,%20Franck&LORENZO,%20Louis-Etienne&GRIVET,%20Zoe&BOUALI-BENAZZOUZ,%20Rabia&MARTIN,%20Hugo&rft.genre=article |
