COSTEDOAT, Ingrid; MASSON, Maeva; DUFFAU, Pierre; LAZARO, Estibaliz; RICHEZ, Christophe; TRUCHETET, Marie Elise

doi:10.2340/00015555-3839

DUFFAU, Pierre
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Article de revue

Ce document a été publié dans

Acta Dermato-Venereologica. 2021-05-27, vol. 101, n° 6

Résumé en anglais

The management of digital ulcers in systemic sclerosis is difficult. While the 2017 European League Against Rheumatism (EULAR) guidelines clearly defined the use of systemic therapies for digital ulcers, little is known about the efficacy of locoregional treatments. The aim of this review is to systematically assess the spectrum of published locoregional therapies for digital ulcers. A total of 58 studies were included. Among the different locoregional treatment strategies descri-bed, injections of fat-derived cells and botulinum toxin showed promising results in the reduction of pain and the number of digital ulcers. By contrast, this review found that sympathectomy yielded disappointing re-sults, with low rates of effectiveness and frequent recurrence. For other treatments, such as hyperbaric oxygen therapy, phototherapy (ultraviolet A), low-level light therapy, intermittent compression, Waon therapy, extracorporeal shockwave, vitamin E gel, and topical dimethyl sulphoxide, the conflicting results or limited published data reflected the low level of evi-dence. Larger randomized clinical trials are required to confirm the validity of promising techniques.< Réduire

Mots clés en anglais

Botulinum toxin

Digital ulcers

Fat-derived cells

Systematic re-view

Systemic sclerosis

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170263

DOI

http://dx.doi.org/10.2340/00015555-3839

Unités de recherche

ImmunoConcEpT - UMR 5164

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Locoregional treatments for digital ulcers in systemic sclerosis: A systematic review

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Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche