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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDECOEUR, Fanny
dc.contributor.authorPICARD, Katherine
dc.contributor.authorST‐PIERRE, Marie‐Kim
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGREENHALGH, Andrew D.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELPECH, Jean-Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSERE, Alexandra
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.contributor.authorTREMBLAY, Marie-Eve
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorNADJAR, Agnes
dc.date.accessioned2022-11-08T15:18:43Z
dc.date.available2022-11-08T15:18:43Z
dc.date.issued2022-02-10
dc.identifier.issn1662-5102en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170232
dc.description.abstractEnOver the last century, westernization of dietary habits has led to a dramatic reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). In particular, low maternal intake of n-3 PUFAs throughout gestation and lactation causes defects in brain myelination. Microglia are recognized for their critical contribution to neurodevelopmental processes, such as myelination. These cells invade the white matter in the first weeks of the post-natal period, where they participate in oligodendrocyte maturation and myelin production. Therefore, we investigated whether an alteration of white matter microglia accompanies the myelination deficits observed in the brain of n-3 PUFA-deficient animals. Macroscopic imaging analysis shows that maternal n-3 PUFA deficiency decreases the density of white matter microglia around post-natal day 10. Microscopic electron microscopy analyses also revealed alterations of microglial ultrastructure, a decrease in the number of contacts between microglia and myelin sheet, and a decreased amount of myelin debris in their cell body. White matter microglia further displayed increased mitochondrial abundance and network area under perinatal n-3 PUFA deficiency. Overall, our data suggest that maternal n-3 PUFA deficiency alters the structure and function of microglial cells located in the white matter of pups early in life, and this could be the key to understand myelination deficits during neurodevelopment. Copyright © 2022 Decoeur, Picard, St-Pierre, Greenhalgh, Delpech, Sere, Layé, Tremblay and Nadjar.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.description.sponsorshipUniversity of Bordeaux Neurocampus Graduate Schoolen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAmyloid Precursor Protein
dc.subject.enMyelin
dc.subject.enOmega 3 Fatty Acid
dc.subject.enAdult
dc.subject.enAnimal Experiment
dc.subject.enAnimal Model
dc.subject.enAnimal Tissue
dc.subject.enArticle
dc.subject.enAstrocyte
dc.subject.enBrain Cortex
dc.subject.enCell Survival
dc.subject.enConfocal Microscopy
dc.subject.enControlled Study
dc.subject.enCorpus Callosum
dc.subject.enDiet Supplementation
dc.subject.enElectron Microscopy
dc.subject.enEnzyme Deficiency
dc.subject.enGene
dc.subject.enHead Circumference
dc.subject.enHippocampal Ca1 Region
dc.subject.enImmunocytochemistry
dc.subject.enImmunohistochemistry
dc.subject.enIonized Calcium Binding Adapter Molecule 1 Gene
dc.subject.enLactation
dc.subject.enMale
dc.subject.enMaternal Behavior
dc.subject.enMesencephalon
dc.subject.enMicroglia
dc.subject.enMouse
dc.subject.enMyelination
dc.subject.enNerve Cell Differentiation
dc.subject.enNonhuman
dc.subject.enOligodendroglia
dc.subject.enPostsynaptic Density
dc.subject.enSpinal Muscular Atrophy
dc.subject.enTransmission Electron Microscopy
dc.subject.enUltrastructure
dc.subject.enWhite Matter
dc.title.enN-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice
dc.title.alternativeFront Cell Neurosci.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fncel.2022.802411en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35221920en_US
bordeaux.journalFrontiers in Cellular Neuroscienceen_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRAEen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.teamNutriPsyen_US
bordeaux.teamNutriMinden_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional, Île-de-Franceen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDFonds de recherche du Québec – Nature et technologiesen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDCanadian Institutes of Health Researchen_US
bordeaux.identifier.funderIDFonds de Recherche du Québec - Santéen_US
hal.identifierhal-03844299
hal.version1
hal.date.transferred2022-11-08T15:18:53Z
hal.exporttrue
dc.rights.ccCC BYen_US
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