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N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice
NADJAR, Agnes
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Idioma
EN
Article de revue
Este ítem está publicado en
Frontiers in Cellular Neuroscience. 2022-02-10, vol. 16
Resumen en inglés
Over the last century, westernization of dietary habits has led to a dramatic reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). In particular, low maternal intake of n-3 PUFAs throughout gestation ...Leer más >
Over the last century, westernization of dietary habits has led to a dramatic reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). In particular, low maternal intake of n-3 PUFAs throughout gestation and lactation causes defects in brain myelination. Microglia are recognized for their critical contribution to neurodevelopmental processes, such as myelination. These cells invade the white matter in the first weeks of the post-natal period, where they participate in oligodendrocyte maturation and myelin production. Therefore, we investigated whether an alteration of white matter microglia accompanies the myelination deficits observed in the brain of n-3 PUFA-deficient animals. Macroscopic imaging analysis shows that maternal n-3 PUFA deficiency decreases the density of white matter microglia around post-natal day 10. Microscopic electron microscopy analyses also revealed alterations of microglial ultrastructure, a decrease in the number of contacts between microglia and myelin sheet, and a decreased amount of myelin debris in their cell body. White matter microglia further displayed increased mitochondrial abundance and network area under perinatal n-3 PUFA deficiency. Overall, our data suggest that maternal n-3 PUFA deficiency alters the structure and function of microglial cells located in the white matter of pups early in life, and this could be the key to understand myelination deficits during neurodevelopment. Copyright © 2022 Decoeur, Picard, St-Pierre, Greenhalgh, Delpech, Sere, Layé, Tremblay and Nadjar.< Leer menos
Palabras clave en inglés
Amyloid Precursor Protein
Myelin
Omega 3 Fatty Acid
Adult
Animal Experiment
Animal Model
Animal Tissue
Article
Astrocyte
Brain Cortex
Cell Survival
Confocal Microscopy
Controlled Study
Corpus Callosum
Diet Supplementation
Electron Microscopy
Enzyme Deficiency
Gene
Head Circumference
Hippocampal Ca1 Region
Immunocytochemistry
Immunohistochemistry
Ionized Calcium Binding Adapter Molecule 1 Gene
Lactation
Male
Maternal Behavior
Mesencephalon
Microglia
Mouse
Myelination
Nerve Cell Differentiation
Nonhuman
Oligodendroglia
Postsynaptic Density
Spinal Muscular Atrophy
Transmission Electron Microscopy
Ultrastructure
White Matter
Proyecto ANR
Développment d'une infrastructure française distribuée coordonnée
University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028
University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028
Centros de investigación