CUNY, Thomas; BUCHFELDER, Michael; DUFOUR, Henry; GROSSMAN, Ashley; GATTA-CHERIFI, Blandine; JOUANNEAU, Emmanuel; RAVEROT, Gerald; VASILJEVIC, Alexandre; CASTINETTI, Frederic

doi:10.3390/cancers14153831

Langue

Article de revue

Ce document a été publié dans

Cancers. 2022-08-07, vol. 14, n° 15, p. 3831

Résumé en anglais

Craniopharyngiomas (CPs) are rare tumors of the skull base, developing near the pituitary gland and hypothalamus and responsible for severe hormonal deficiencies and an overall increase in mortality rate. While surgery and radiotherapy represent the recommended first-line therapies for CPs, a new paradigm for treatment is currently emerging, as a consequence of accumulated knowledge concerning the molecular mechanisms involved in tumor growth, paving the way for anticipated use of targeted therapies. Significant clinical and basic research conducted in the field of CPs will undoubtedly constitute a real step forward for a better understanding of the behavior of these tumors and prevent associated complications. In this review, our aim is to summarize the multiple steps in the management of CPs in adults and emphasize the most recent studies that will contribute to advancing the diagnostic and therapeutic algorithms. © 2022 by the authors.< Réduire

Mots clés en anglais

Craniopharyngioma

Adamantinomatous

Papillary

Targeted therapies

Radiotherapy

Neurosurgery

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170223

DOI

http://dx.doi.org/10.3390/cancers14153831

Unités de recherche

Neurocentre Magendie - U1215

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

The Challenging Management of Craniopharyngiomas in Adults: Time for a Reappraisal?

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche