RODRIGUEZ-IGLESIAS, Noelia; NADJAR, Agnes; SIERRA, Amanda; VALERO, Jorge

doi:10.3390/ijms23063399

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

SIERRA, Amanda

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Article de revue

Ce document a été publié dans

International Journal of Molecular Sciences. 2022-03-21, vol. 23, n° 6, p. 3399

Résumé en anglais

Maternal intake of omega-3 (n-3 PUFAs) and omega-6 (n-6 PUFAs) polyunsaturated fatty acids impacts hippocampal neurogenesis during development, an effect that may extend to adulthood by altering adult hippocampal neurogenesis (AHN). The n-3 PUFAs and n-6 PUFAs are precursors of inflammatory regulators that potentially affect AHN and glia. Additionally, n-3 PUFA dietary supplementation may present a sexually dimorphic action in the brain. Therefore, we postulated that dietary n-6/n-3 PUFA balance shapes the adult DG in a sex-dependent manner influencing AHN and glia. We test our hypothesis by feeding adult female and male mice with n-3 PUFA balanced or deficient diets. To analyze the immunomodulatory potential of the diets, we injected mice with the bacterial endotoxin lipopolysaccharide (LPS). LPS reduced neuroblast number, and its effect was exacerbated by the n-3 PUFA-deficient diet. The n-3 PUFA-deficient diet reduced the DG volume, AHN, microglia number, and surveilled volume. The diet effect on most mature neuroblasts was exclusively significant in female mice. Colocalization and multivariate analysis revealed an association between microglia and AHN, as well as the sexual dimorphic effect of diet. Our study reveals that female mice are more susceptible than males to the effect of dietary n-6/n-3 PUFA ratio on AHN and microglia. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.< Réduire

Mots clés en anglais

Alpha Tocopherol

Aminobenzoic Acid

Arachidonic Acid

Biotin

Choline

Colecalciferol

Cyanocobalamin

Endotoxin

Fatty Acid

Folic Acid

Inositol

Linoleic Acid

Lipopolysaccharide

Methionine

Nicotinic Acid

Omega 3 Fatty Acid

Omega 6 Fatty Acid

Pantothenate Calcium

Polyunsaturated Fatty Acid

Pyridoxine

Retinol Acetate

Riboflavin

Adult

Animal Experiment

Animal Model

Animal Tissue

Article

Brain Tissue

Confocal Laser Scanning Microscopy

Controlled Study

Diet Supplementation

Drug Sensitivity

Epifluorescence Microscopy

Female

Gas Chromatography

Glia

Image Segmentation

Immunofluorescence

Immunohistochemistry

Inflammation

Male

Microglia

Mouse

Nervous System Development

Neuroblast

Neuroprotection

Nonhuman

Nutritional Deficiency

Sex Difference

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170197

DOI

http://dx.doi.org/10.3390/ijms23063399

Unités de recherche

Neurocentre Magendie - U1215

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Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

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Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche