The production of wax esters in transgenic plants: towards a sustainable source of bio-lubricants.

DOMERGUE, Frédéric; MIKLASZEWSKA, Magdalena

doi:10.1093/jxb/erac046

Laboratoire de biogenèse membranaire [LBM]

MIKLASZEWSKA, Magdalena

Langue

Article de revue

Ce document a été publié dans

Journal of Experimental Botany. 2022-05-13, vol. 73, n° 9, p. 2817-2834

Résumé en anglais

Wax esters are high-value compounds used as feedstocks for the production of lubricants, pharmaceuticals, and cosmetics. Currently, they are produced mostly from fossil reserves using chemical synthesis, but this cannot meet increasing demand and has a negative environmental impact. Natural wax esters are also obtained from Simmondsia chinensis (jojoba) but comparably in very low amounts and expensively. Therefore, metabolic engineering of plants, especially of the seed storage lipid metabolism of oil crops, represents an attractive strategy for renewable, sustainable, and environmentally friendly production of wax esters tailored to industrial applications. Utilization of wax ester-synthesizing enzymes with defined specificities and modulation of the acyl-CoA pools by various genetic engineering approaches can lead to obtaining wax esters with desired compositions and properties. However, obtaining high amounts of wax esters is still challenging due to their negative impact on seed germination and yield. In this review, we describe recent progress in establishing non-food-plant platforms for wax ester production and discuss their advantages and limitations as well as future prospects.< Réduire

Mots clés en anglais

Esters

Lubricants

Metabolic Engineering

Plants

Genetically Modified

Waxes

Fatty acyl reductase

Green factory

Oilseed crops

Plant metabolic engineering

Wax esters

Wax synthase

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170103

DOI

http://dx.doi.org/10.1093/jxb/erac046

Unités de recherche

Laboratoire de Biogenèse Membranaire (LBM) - UMR 5200

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