GAKIÈRE, Bertrand; FERNIE, Alisdair R; PÉTRIACQ, Pierre

doi:10.1016/j.freeradbiomed.2018.01.003

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GAKIÈRE, Bertrand
Institut des Sciences des Plantes de Paris-Saclay [IPS2 (UMR_9213 / UMR_1403)]

FERNIE, Alisdair R
Max Planck Institute of Molecular Plant Physiology [MPI-MP]

PÉTRIACQ, Pierre
Biologie du fruit et pathologie [BFP]
University of Sheffield

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Ce document a été publié dans

Free Radical Biology and Medicine. 2018, vol. 122, p. 86-95

Elsevier

Résumé en anglais

Since its discovery more than a century ago, nicotinamide adenine dinucleotide (NAD+) is recognised as a fascinating cornerstone of cellular metabolism. This ubiquitous energy cofactor plays vital roles in metabolic pathways and regulatory processes, a fact emphasised by the essentiality of a balanced NAD+ metabolism for normal plant growth and development. Research on the role of NAD in plants has been predominantly carried out in the model plant Arabidopsis thaliana (Arabidopsis) with emphasis on the redox properties and cellular signalling functions of the metabolite. This review examines the current state of knowledge concerning how NAD can regulate both metabolic pools and gene expression in Arabidopsis. Particular focus is placed on recent studies highlighting the complexity of metabolic regulations involving NAD, more particularly in the mitochondrial compartment, and of signalling roles with respect to interactions with environmental fluctuations most specifically those involving plant immunity.< Réduire

Mots clés

Pyridine nucleotides

Mots clés en anglais

Cellular signalling

Mitochondrial function

NAD(+)

Plant immunity

Redox

Metabolic regulation