MA, Q. X.; ARNEODO, A.; DING, G. H.; ARGOUL, Françoise

doi:10.1007/s00422-017-0712-3

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MA, Q. X.
Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function

ARNEODO, A.
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]

DING, G. H.
Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function

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Biological Cybernetics (Modeling). 2017, vol. 111, n° 2, p. 129-148

Springer Verlag

Résumé en anglais

Alteration of Na v channel functions (channe-lopathies) has been encountered in various hereditary muscle diseases. Na v channel mutations lead to aberrant excitabil-ity in skeletal muscle myotonia and paralysis. In general, these mutations disable inactivation of the Na v channel, producing either repetitive action potential firing (myotonia) or electrical dormancy (flaccid paralysis) in skeletal muscles. These " sick-excitable " cell conditions were shown to correlate with a mechanical stretch-driven left shift of the conductance factors of the two gating mechanisms of a fraction of Na v channels, which make them firing at inappropriate hyperpolarised (left-shifted) voltages. Here we elaborate on a variant of the Hodgkin–Huxley model that includes a stretch elasticity energy component in the activation and inactivation gate kinetic rates. We show that this model reproduces fairly well sick-excitable cell behaviour and can be used to predict the parameter domains where aberrant excitability or paralysis may occur. By allowing us to separate the incidences of activation and inactivation gate impairments in Na v channel excitability, this model could be a strong asset for diagnosing the origin of excitable cell disorders.< Réduire

Mots clés en anglais

Na v voltage-gated channels

Mechanical stress

Dynamical systems

Excitable cell disorders

Sick-excitable cell

Periodic firing and myotonia

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Dynamical study of Na v channel excitability under mechanical stress

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