LAPERROUSAZ, B.; DRILLON, G.; BERGUIGA, L.; NICOLINI, F.; AUDIT, B.; SATTA, V. M.; ARNEODO, A.; ARGOUL, Françoise

doi:10.1063/1.4960259

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LAPERROUSAZ, B.
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]

DRILLON, G.
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]

BERGUIGA, L.

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Communication dans un congrès

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2016-03-22, Tomsk. 2016-08-02, vol. 1760, p. 020040

Résumé en anglais

Soft materials such as polymer gels, synthetic biomaterials and living biological tissues are generally classified as viscoelastic or viscoplastic materials, because they behave neither as pure elastic solids, nor as pure viscous fluids. When stressed beyond their linear viscoelastic regime, cross-linked biopolymer gels can behave nonlinearly (inelastically) up to failure. In living cells, this type of behavior is more frequent because their cytoskeleton is basically made of cross-linked biopolymer chains with very different structural and flexibility properties. These networks have high sensitivity to stress and great propensity to local failure. But in contrast to synthetic passive gels, they can “afford” these failures because they have ATP driven reparation mechanisms which often allow the recovery of the original texture. A cell pressed in between two plates for a long period of time may recover its original shape if the culture medium brings all the nutrients for keeping it alive. When the failure e...< Réduire

Mots clés en anglais

Cancer

Biopolymer

Gels

Materials behavior

Cytoskeleton

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From Elasticity to Inelasticity in Cancer Cell Mechanics: a Loss of Scale-Invariance

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