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From Elasticity to Inelasticity in Cancer Cell Mechanics: a Loss of Scale-Invariance

hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
dc.contributor.authorLAPERROUSAZ, B.
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorDRILLON, G.
dc.contributor.authorBERGUIGA, L.
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
hal.structure.identifierHospices Civils de Lyon [HCL]
dc.contributor.authorNICOLINI, F.
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorAUDIT, B.
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
dc.contributor.authorSATTA, V. M.
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorARNEODO, A.
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorARGOUL, Françoise
dc.contributor.editorGutmanas
dc.contributor.editorE. Y. and Naimark
dc.contributor.editorO. B. and Sharkeev
dc.contributor.editorY. P.
dc.date.issued2016-08-02
dc.date.conference2016-03-22
dc.description.abstractEnSoft materials such as polymer gels, synthetic biomaterials and living biological tissues are generally classified as viscoelastic or viscoplastic materials, because they behave neither as pure elastic solids, nor as pure viscous fluids. When stressed beyond their linear viscoelastic regime, cross-linked biopolymer gels can behave nonlinearly (inelastically) up to failure. In living cells, this type of behavior is more frequent because their cytoskeleton is basically made of cross-linked biopolymer chains with very different structural and flexibility properties. These networks have high sensitivity to stress and great propensity to local failure. But in contrast to synthetic passive gels, they can “afford” these failures because they have ATP driven reparation mechanisms which often allow the recovery of the original texture. A cell pressed in between two plates for a long period of time may recover its original shape if the culture medium brings all the nutrients for keeping it alive. When the failure e...
dc.language.isoen
dc.subject.enCancer
dc.subject.enBiopolymer
dc.subject.enGels
dc.subject.enMaterials behavior
dc.subject.enCytoskeleton
dc.title.enFrom Elasticity to Inelasticity in Cancer Cell Mechanics: a Loss of Scale-Invariance
dc.typeCommunication dans un congrès
dc.identifier.doi10.1063/1.4960259
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.page020040
bordeaux.volume1760
bordeaux.countryRU
bordeaux.conference.cityTomsk
bordeaux.peerReviewednon
hal.identifierhal-01556050
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2016-03-25
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01556050v1
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