CORVIS, Yohann; NÉGRIER, Philippe; ESPEAU, Philippe

doi:10.1002/jps.22727

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

CORVIS, Yohann
Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM]

NÉGRIER, Philippe
Laboratoire Ondes et Matière d'Aquitaine [LOMA]

ESPEAU, Philippe
Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM]

Langue

Article de revue

Ce document a été publié dans

Journal of Pharmaceutical Sciences. 2011, vol. 100, n° 12, p. 5235-5243

Wiley

Résumé en anglais

The aim of this study was to investigate the solid dispersion phase behavior of s- or rs-ibuprofen in stearic acid. By means of thermal analysis, we have demonstrated the total immiscibility, in solid state, of the corresponding binary mixtures. This indicates that no specific interactions exist between the chosen excipient and active pharmaceutical ingredient (API) that lead to eutectic systems. Furthermore, based on calorimetric and X-ray diffraction experiments, we have showed that upon cooling of the molten state, only stearic acid recrystallizes in the presence of s-ibuprofen, whereas a quaternary phase mixture is obtained for the racemic ibuprofen/stearic acid preparation. The solubility of stearic acid in s-ibuprofen liquid in all proportions was also determined. Overall, the results presented here offer an approach for the study of API/excipient interactions.< Réduire

Mots clés en anglais

miscibility

melt-recrystallization process

solubility

polymorphism

solid-state stability

phase diagram

drug-excipient interactions

thermal analysis

X-ray powder diffraction

drug–excipient interactions

Métadonnées

Licence d’utilisation du document

Physicochemical Stability of Solid Dispersions of Enantiomeric or Racemic Ibuprofen in Stearic Acid

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

DOI

Origine

Unités de recherche