The Modified Bidomain Model with Diffusive Inclusions
COUDIÈRE, Yves
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
DAVIDOVIĆ, Anđela
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
COUDIÈRE, Yves
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
DAVIDOVIĆ, Anđela
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
< Leer menos
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
Idioma
en
Autre communication scientifique (congrès sans actes - poster - séminaire...)
Este ítem está publicado en
Computing in Cardiology — 41st Annual Conference, 2014-09-07, Cambridge, Massachusetts. 2014-09-07
Resumen en inglés
Bidomain equations are the standard way to model the electric potential in cardiac tissue. They are based on the fact that active cardiomyocytes are present everywhere in the heart, while it is known that non-small regions ...Leer más >
Bidomain equations are the standard way to model the electric potential in cardiac tissue. They are based on the fact that active cardiomyocytes are present everywhere in the heart, while it is known that non-small regions exist where additional extracellular media take place. These regions, which play an important role in diseased hearts, are often taken into account through ad-hoc rough tuning of the tissue conductivities. In this work, we introduce a rigorous way to derive these conductivities from a microscopic description of the heterogeneities in the tissue. We assume a periodic alternation of the healthy tissue and the fibrotic tissue. Such a microscopic model can be simulated directly, at the price of a very high computational cost. Instead we derive a homogenized model at the macroscopic scale, following a standard multiscale technique.We recover a bidomain type model, but with modified conductivities, that depend on the volume fraction of the diffusive inclusions but also on their geometries. The numerical results confirm the convergence of the microscopic model to the homogenized equations. We observe the influence of the diffusive inclusions on the propagation of action potentials. With the final model we shall provide cheap modeling tools to account for tissue heterogeneities at intermediate scales. The diffusive volume ratio, that enters the model, might be available through functional imaging, which enlightens the practical interest of the method.< Leer menos
Palabras clave en inglés
Homogenisation
Electrophysiology
Cardiology
Bidomain model
Orígen
Importado de HalCentros de investigación