RENNER, Marianne L.; COGNET, Laurent; LOUNIS, Brahim; TRILLER, Antoine; CHOQUET, Daniel

doi:10.1016/j.neuropharm.2008.07.022

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RENNER, Marianne L.
Physiologie cellulaire de la synapse [PCS]

COGNET, Laurent
Centre de physique moléculaire optique et hertzienne [CPMOH]

LOUNIS, Brahim
Centre de physique moléculaire optique et hertzienne [CPMOH]

Langue

Article de revue

Ce document a été publié dans

Neuropharmacology. 2009-01, vol. 56, n° 1, p. 30-36

Elsevier

Résumé en anglais

Receptors are concentrated in the postsynaptic membrane but can enter and exit synapses rapidly during both basal turnover and processes of synaptic plasticity. How the exchange of receptors by lateral diffusion between synaptic and extrasynaptic areas is regulated remains largely unknown. We investigated the structural properties of the postsynaptic membrane that allow these movements by addressing the diffusion behaviors of AMPA receptors (AMPARs) and different lipids. Using single molecule tracking we found that not only AMPARs but also lipids, which are not synaptically enriched, display confined diffusion at synapses. Each molecule type displays a different average confinement area, smaller molecules being confined to smaller areas. Glutamate application increases the mobility of all molecules. The structure of the synaptic membrane is thus probably organized as a size exclusion matrix and this controls the rate of exchange of molecules with the extrasynaptic membrane.< Réduire

Mots clés en anglais

Postsynaptic density

Synaptic transmission

Brownian diffusion

Single molecule tracking

AMPA receptors

Lipids

DOI

http://dx.doi.org/10.1016/j.neuropharm.2008.07.022

Projet Européen

QLG3-CT-2001-02089

Origine

Importé de hal

Unités de recherche

Laboratoire Ondes et Matière d'Aquitaine (LOMA) - UMR 5798