The excitatory postsynaptic density is a size exclusion diffusion environment
| hal.structure.identifier | Physiologie cellulaire de la synapse [PCS] | |
| dc.contributor.author | RENNER, Marianne L. | |
| hal.structure.identifier | Centre de physique moléculaire optique et hertzienne [CPMOH] | |
| dc.contributor.author | COGNET, Laurent | |
| hal.structure.identifier | Centre de physique moléculaire optique et hertzienne [CPMOH] | |
| dc.contributor.author | LOUNIS, Brahim | |
| hal.structure.identifier | Biologie Cellulaire de la Synapse Normale et Pathologique | |
| dc.contributor.author | TRILLER, Antoine | |
| hal.structure.identifier | Physiologie cellulaire de la synapse [PCS] | |
| dc.contributor.author | CHOQUET, Daniel | |
| dc.date.created | 2008-04-29 | |
| dc.date.issued | 2009-01 | |
| dc.identifier.issn | 0028-3908 | |
| dc.description.abstractEn | Receptors are concentrated in the postsynaptic membrane but can enter and exit synapses rapidly during both basal turnover and processes of synaptic plasticity. How the exchange of receptors by lateral diffusion between synaptic and extrasynaptic areas is regulated remains largely unknown. We investigated the structural properties of the postsynaptic membrane that allow these movements by addressing the diffusion behaviors of AMPA receptors (AMPARs) and different lipids. Using single molecule tracking we found that not only AMPARs but also lipids, which are not synaptically enriched, display confined diffusion at synapses. Each molecule type displays a different average confinement area, smaller molecules being confined to smaller areas. Glutamate application increases the mobility of all molecules. The structure of the synaptic membrane is thus probably organized as a size exclusion matrix and this controls the rate of exchange of molecules with the extrasynaptic membrane. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.subject.en | Postsynaptic density | |
| dc.subject.en | Synaptic transmission | |
| dc.subject.en | Brownian diffusion | |
| dc.subject.en | Single molecule tracking | |
| dc.subject.en | AMPA receptors | |
| dc.subject.en | Lipids | |
| dc.title.en | The excitatory postsynaptic density is a size exclusion diffusion environment | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.neuropharm.2008.07.022 | |
| dc.subject.hal | Sciences du Vivant [q-bio] | |
| dc.description.sponsorshipEurope | QLG3-CT-2001-02089 | |
| bordeaux.journal | Neuropharmacology | |
| bordeaux.page | 30-36 | |
| bordeaux.volume | 56 | |
| bordeaux.issue | 1 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00506460 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00506460v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropharmacology&rft.date=2009-01&rft.volume=56&rft.issue=1&rft.spage=30-36&rft.epage=30-36&rft.eissn=0028-3908&rft.issn=0028-3908&rft.au=RENNER,%20Marianne%20L.&COGNET,%20Laurent&LOUNIS,%20Brahim&TRILLER,%20Antoine&CHOQUET,%20Daniel&rft.genre=article |
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