| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | ARISTIETA, Asier | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BARRESI, Massimo | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | AZIZPOUR LINDI, Shiva | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | BARRIERE, Gregory | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COURTAND, Gilles | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | DE LA CROMPE, Brice | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | GUILHEMSANG, Lise | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | GAUTHIER, Sophie | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | FIORAMONTI, Stephanie | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BAUFRETON, Jerome | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | MALLET, Nicolas | |
| dc.date.accessioned | 2022-10-10T10:11:38Z | |
| dc.date.available | 2022-10-10T10:11:38Z | |
| dc.date.issued | 2020-12-01 | |
| dc.identifier.issn | 0960-9822 | en_US |
| dc.identifier.uri | oai:crossref.org:10.1016/j.cub.2020.11.019 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/148370 | |
| dc.description.abstractEn | The basal ganglia (BG) inhibit movements through two independent circuits: the striatal neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert opposite effects onto external globus pallidus (GPe) neurons, whose functional importance as a relay has changed drastically with the discovery of two distinct cell types, namely the prototypic and the arkypallidal neurons. However, little is known about the synaptic connectivity scheme of different GPe neurons toward both motor-suppressing pathways, as well as how opposite changes in GPe neuronal activity relate to locomotion inhibition. Here, we optogenetically dissect the input organizations of prototypic and arkypallidal neurons and further define the circuit mechanism and behavioral outcome associated with activation of the indirect or hyperdirect pathways. This work reveals that arkypallidal neurons are part of a novel disynaptic feedback loop differentially recruited by the indirect or hyperdirect pathways and that broadcasts inhibitory control onto locomotion only when arkypallidal neurons increase their activity. | |
| dc.description.sponsorship | Analyse électrophysiologique de la dynamique des réseaux des ganglions de la base en situation normale et Parkinsonienne par une approche de manipulation optogénétique sélective de circuit neuronal - ANR-14-CE13-0024 | en_US |
| dc.description.sponsorship | Diversité neuronale du Globus Pallidus: du profilage moléculaire à la fonction dans le contrôle du mouvement - ANR-15-CE37-0006 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject.en | External globus pallidus | |
| dc.subject.en | Prototypic and arkypallidal neurons | |
| dc.subject.en | Optogenetic manipulation | |
| dc.subject.en | Indirect pathway | |
| dc.subject.en | Subthalamic nucleus | |
| dc.subject.en | Disynaptic loop | |
| dc.subject.en | Inhibitory locomotion control | |
| dc.title.en | A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.cub.2020.11.019 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 33306949 | en_US |
| bordeaux.journal | Current Biology - CB | en_US |
| bordeaux.page | 707-721 | en_US |
| bordeaux.volume | 31 | en_US |
| bordeaux.hal.laboratories | Institut des Maladies Neurodégénératives (IMN) - UMR 5293 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Association France Parkinson | en_US |
| bordeaux.import.source | dissemin | |
| hal.identifier | hal-02988871 | |
| hal.version | 2 | |
| hal.export | false | |
| workflow.import.source | dissemin | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology%20-%20CB&rft.date=2020-12-01&rft.volume=31&rft.issue=4&rft.spage=707-721&rft.epage=707-721&rft.eissn=0960-9822&rft.issn=0960-9822&rft.au=ARISTIETA,%20Asier&BARRESI,%20Massimo&AZIZPOUR%20LINDI,%20Shiva&BARRIERE,%20Gregory&COURTAND,%20Gilles&rft.genre=article | |
