A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition
Language
EN
Article de revue
This item was published in
Current Biology - CB. 2020-12-01, vol. 31, n° 4, p. 707-721
English Abstract
The basal ganglia (BG) inhibit movements through two independent circuits: the striatal neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert opposite effects onto external globus pallidus ...Read more >
The basal ganglia (BG) inhibit movements through two independent circuits: the striatal neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert opposite effects onto external globus pallidus (GPe) neurons, whose functional importance as a relay has changed drastically with the discovery of two distinct cell types, namely the prototypic and the arkypallidal neurons. However, little is known about the synaptic connectivity scheme of different GPe neurons toward both motor-suppressing pathways, as well as how opposite changes in GPe neuronal activity relate to locomotion inhibition. Here, we optogenetically dissect the input organizations of prototypic and arkypallidal neurons and further define the circuit mechanism and behavioral outcome associated with activation of the indirect or hyperdirect pathways. This work reveals that arkypallidal neurons are part of a novel disynaptic feedback loop differentially recruited by the indirect or hyperdirect pathways and that broadcasts inhibitory control onto locomotion only when arkypallidal neurons increase their activity.Read less <
English Keywords
External globus pallidus
Prototypic and arkypallidal neurons
Optogenetic manipulation
Indirect pathway
Subthalamic nucleus
Disynaptic loop
Inhibitory locomotion control
ANR Project
Analyse électrophysiologique de la dynamique des réseaux des ganglions de la base en situation normale et Parkinsonienne par une approche de manipulation optogénétique sélective de circuit neuronal - ANR-14-CE13-0024
Diversité neuronale du Globus Pallidus: du profilage moléculaire à la fonction dans le contrôle du mouvement - ANR-15-CE37-0006
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Diversité neuronale du Globus Pallidus: du profilage moléculaire à la fonction dans le contrôle du mouvement - ANR-15-CE37-0006
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043