BUSQUETS-GARCIA, Arnau; MELIS, Miriam; BELLOCCHIO, Luigi; MARSICANO, Giovanni

doi:10.1111/ejn.15618

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

European Journal of Neuroscience. 2022-02-01, vol. 55, n° 4, p. 903-908

Résumé en anglais

The endocannabinoid system is widely expressed both in the brain and in the periphery. This system regulates a plethora of physiological functions and is composed of cannabinoid receptors, their endogenous ligands, and the enzymes involved in their metabolic processes. In the last few years, the development of new imaging and molecular tools has demonstrated that these receptors are distributed in many cell types (e.g., neuronal or glial cells) and intracellular compartments (e.g., mitochondria). Interestingly, cellular or molecular effects are differentially mediated by cannabinoid receptors according to their specific localization in different cell-types or in different subcellular locations. Moreover, the endocannabinoid system is also expressed throughout the body where it can serve to modulate the connection between the brain and the periphery. Finally, better understanding of the cannabinoid receptors structure and pharmacology has led researchers to propose interesting and new allosteric modulators of synaptic communication. The latest advances and innovative research in the cannabinoid field will provide new insights and better approaches to improve its interesting potential therapeutic profile. This special issue intends to bring together a series of empirical papers, targeted reviews and opinions from leaders in the field that will highlight the new advances in cannabinoid research.< Réduire

Mots clés en anglais

Brain

Cannabinoid Receptor Modulators

Cannabinoids

Endocannabinoids

Receptors

Cannabinoid

Signal Transduction

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140542

DOI

http://dx.doi.org/10.1111/ejn.15618

Projet Européen

Neurocircuitry of endocannabinoid regulation of food intake
Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes

Project ANR

Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes.
Représentation sensorielle lors d'états psychotiques - ANR-16-CE37-0010
Role du recepteur CB1 mitocondriel du tissue adipeux dans la regulation de la balance energetique - ANR-19-CE14-0039
Les récepteurs couplés aux protéines G mitochondriaux en neuroprotection - ANR-19-CE16-0025
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043

Unités de recherche

Neurocentre Magendie - U1215

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Special issue editorial: Cannabinoid signalling in the brain: New vistas.