GENTREAU, Melissa; RAYMOND, Michel; SAMIERI, Cecilia; CHUY, Virginie; FEART-COURET, Catherine; BERTICAT, Claire; ARTERO, Sylvaine

doi:10.3390/nu14122485

Bordeaux population health [BPH]

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Article de revue

Ce document a été publié dans

Nutrients. 2022-06-15, vol. 14, n° 12

Résumé en anglais

Previous studies have highlighted links between a high-glycemic-load (GL) diet and Alzheimer's disease in apolipoprotein E ε4 (APOE4) carriers. However, the impact of high-GL diet on plasma amyloid-β (Aβ), an Alzheimer's disease hallmark that can be detected decades before clinical symptomatology, is unknown. This study examined the association between plasma Aβ peptides (Aβ(40), Aβ(42) concentration and Aβ(42)/Aβ(40) ratio) and GL. The influence of the GL of four meal types (breakfast, lunch, afternoon snack, and dinner) was also determined. From the prospective Three-City study, 377 participants with plasma Aβ measurements, and who completed the Food Frequency Questionnaire, were selected. The association between plasma Aβ and GL was tested using an adjusted linear regression model. Lunch GL was associated with a lower plasma Aβ(42) concentration (β = -2.2 [CI = -4.27, -0.12], p = 0.038) and lower Aβ(42)/Aβ(40) ratio (β = -0.009 [CI = -0.0172, -0.0007], p = 0.034) in the model adjusted for center, age, sex, education level, APOE4 status, energy intake, serum creatinine, total cholesterol, and Mediterranean-like diet. No significant association was found with the GL of the other meal types. These results suggest that dietary GL may independently modulate the plasma Aβ of the APOE4 status. The mechanism underlying diet, metabolic response, and Aβ peptide regulation must be elucidated.< Réduire

Mots clés en anglais

Glycemic load

Refined carbohydrate

Amyloid-β

Alzheimer’s disease

Biomarker

Cohort

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140495

DOI

http://dx.doi.org/10.3390/nu14122485

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Dietary Glycemic Load and Plasma Amyloid-β Biomarkers of Alzheimer's Disease

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