PIGUEL, Nicolas H.; FIEVRE, Sabine; BLANC, Jean-Michel; CARTA, Mario; MOREAU, Maite M.; MOUTIN, Enora; PINHEIRO, Vera L.; MEDINA, Chantal; EZAN, Jerome; LASVAUX, Lea; LOLL, Francois; DURAND, Christelle M.; CHANG, Kai; PETRALIA, Ronald S.; WENTHOLD, Robert J.; STEPHENSON, F. Anne; VUILLARD, Laurent; DARBON, Herve; PERROY, Julie; MULLE, Christophe; MONTCOUQUIOL, Mireille; RACCA, Claudia; SANS, Nathalie

doi:10.1016/j.celrep.2014.09.017

PIGUEL, Nicolas H.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

FIEVRE, Sabine
Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS]

BLANC, Jean-Michel
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

Idioma

Article de revue

Este ítem está publicado en

Cell Reports. 2014-10-23, vol. 9, n° 2, p. 712-727

Resumen en inglés

The appropriate trafficking of glutamate receptors to synapses is crucial for basic synaptic function and synaptic plasticity. It is now accepted that NMDA receptors (NMDARs) internalize and are recycled at the plasma membrane but also exchange between synaptic and extrasynaptic pools; these NMDAR properties are also key to governing synaptic plasticity. Scribble1 is a large PDZ protein required for synaptogenesis and synaptic plasticity. Herein, we show that the level of Scribble1 is regulated in an activity-dependent manner and that Scribble1 controls the number of NMDARs at the plasma membrane. Notably, Scribble1 prevents GluN2A subunits from undergoing lysosomal trafficking and degradation by increasing their recycling to the plasma membrane following NMDAR activation. Finally, we show that a specific YxxR motif on Scribble1 controls these mechanisms through a direct interaction with AP2. Altogether, our findings define a molecular mechanism to control the levels of synaptic NMDARs via Scribble1 complex signaling.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140453

DOI

http://dx.doi.org/10.1016/j.celrep.2014.09.017

Proyecto ANR

Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Caractérisations moléculaire et fonctionnelle de la protéine Scribble 1 au cours du développement du système nerveux central - ANR-07-NEUR-0031
Signalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiques

Centros de investigación

Neurocentre Magendie - U1215

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Scribble1/AP2 Complex Coordinates NMDA Receptor Endocytic Recycling

Idioma

Este ítem está publicado en

Resumen en inglés

URI

DOI

Proyecto ANR

Centros de investigación