EZAN, Jerome; MONTCOUQUIOL, Mireille

doi:10.1016/j.semcdb.2013.03.012

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EZAN, Jerome

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

MONTCOUQUIOL, Mireille

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Seminars in Cell and Developmental Biology. 2013-05-01, vol. 24, n° 5, p. 499-506

Résumé en anglais

Since the first implication of the core planar cell polarity (PCP) pathway in stereocilia orientation of sensory hair cells in the mammalian cochlea, much has been written about this subject, in terms of understanding how this pathway can shape the mammalian hair cells and using the inner ear as a model system to understand mammalian PCP signaling. However, many conflicting results have arisen, leading to puzzling questions regarding the actual mechanism and roles of core PCP signaling in mammals and invertebrates. In this review, we summarize our current knowledge on the establishment of PCP during inner ear development and revisit the contrast between wing epithelial cells in Drosophila melanogaster and sensory epithelia in the mammalian cochlea. Notably, we focus on similarities and differences in the asymmetric distribution of core PCP proteins in the context of cell autonomous versus non-autonomous role of PCP signaling in the two systems. Additionally, we address the relationship between the kinocil- ium position and PCP in cochlear hair cells and increasing results suggest an alternate cell autonomous pathway in regulating PCP in sensory hair cells.< Réduire

Mots clés en anglais

Planar cell polarity

Polarity

Vangl2

Cochlea

Vestibule

Asymmetry

Cilium

Orientation

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140347

DOI

http://dx.doi.org/10.1016/j.semcdb.2013.03.012

Project ANR

Caractérisation moléculaire et fonctionnelle de vangl2 et de ses partenaires chez le mammifère - ANR-08-MNPS-0040

Unités de recherche

Neurocentre Magendie - U1215