MOREAU, Maite; PIGUEL, Nicolas; PAPOUIN, Thomas; KOEHL, Muriel; DURAND, Christelle M.; RUBIO, Maria E.; LOLL, François; RICHARD, Elodie M.; MAZZOCCO, Claire; RACCA, Claudia; OLIET, Stéphane; NORA ABROUS, D.; MONTCOUQUIOL, Mireille; SANS, Nathalie

doi:10.1523/jneurosci.6007-09.2010

Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862

PIGUEL, Nicolas
Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862

PAPOUIN, Thomas
Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862

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The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010-07-21, vol. 30, n° 29, p. 9738-9752

Résumé en anglais

Scribble (Scrib) is a key regulator of apicobasal polarity, presynaptic architecture, and short-term synaptic plasticity in Drosophila. In mammals, its homolog Scrib1 has been implicated in cancer, neural tube closure, and planar cell polarity (PCP), but its specific role in the developing and adult nervous system is unclear. Here, we used the circletail mutant, a mouse model for PCP defects, to show that Scrib1 is located in spines where it influences actin cytoskeleton and spine morphing. In the hippocampus of these mutants, we observed an increased synapse pruning associated with an increased number of enlarged spines and postsynaptic density, and a decreased number of perforated synapses. This phenotype was associated with a mislocalization of the signaling pathway downstream of Scrib1, leading to an overall activation of Rac1 and defects in actin dynamic reorganization. Finally, Scrib1-deficient mice exhibit enhanced learning and memory abilities and impaired social behavior, two features relevant to autistic spectrum disorders. Our data identify Scrib1 as a crucial regulator of brain development and spine morphology, and suggest that Scrib1(crc/+) mice might be a model for studying synaptic dysfunction and human psychiatric disorders.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/140344

DOI

http://dx.doi.org/10.1523/jneurosci.6007-09.2010

Unités de recherche

Neurocentre Magendie - U1215

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The Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function

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