NICOLE, Olivier; BELL, Donald; LESTE-LASSERRE, Thierry; DOAT, Hélène; GUILLEMOT, François; PACARY, Emilie

doi:10.1038/s41380-018-0046-0

Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

BELL, Donald

LESTE-LASSERRE, Thierry
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Ce document a été publié dans

Molecular Psychiatry. 2018-04-30, vol. 23, n° 11, p. 2209-2226

Résumé en anglais

Perturbation of CaMKIIβ expression has been associated with multiple neuropsychiatric diseases, highlighting CaMKIIβ as a gene of interest. Yet, in contrast to CaMKIIα, the specific functions of CaMKIIβ in the brain remain poorly explored. Here, we reveal a novel function for this CaMKII isoform in vivo during neuronal development. By using in utero electroporation, we show that CaMKIIβ is an important regulator of radial migration of projection neurons during cerebral cortex development. Knockdown of CaMKIIβ causes accelerated migration of nascent pyramidal neurons, whereas overexpression of CaMKIIβ inhibits migration, demonstrating that precise regulation of CaMKIIβ expression is required for correct neuronal migration. More precisely, CaMKIIβ controls the multipolar–bipolar transition in the intermediate zone and locomotion in the cortical plate through its actin-binding and -bundling activities. In addition, our data indicate that a fine-tuned balance between CaMKIIβ and cofilin activities is necessary to ensure proper migration of cortical neurons. Thus, our findings define a novel isoform-specific function for CaMKIIβ, demonstrating that CaMKIIβ has a major biological function in the developing brain.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140317

DOI

http://dx.doi.org/10.1038/s41380-018-0046-0

Project ANR

Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043

Unités de recherche

Neurocentre Magendie - U1215

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A novel role for CAMKIIβ in the regulation of cortical neuron migration: implications for neurodevelopmental disorders

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Résumé en anglais

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DOI

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