CHEN, Huaiyou; CELIK, Ali Emre; MUTSCHLER, Angela; COMBES, Antoine; RUNSER, Anne; KLYMCHENKO, Andrey S; LECOMMANDOUX, Sebastien; SERRA, Christophe A; REISCH, Andreas

doi:10.1021/acs.langmuir.2c00534

CHEN, Huaiyou
Université de Strasbourg [UNISTRA]
Laboratoire de Bioimagerie et Pathologies [LBP]

CELIK, Ali Emre
Université de Strasbourg [UNISTRA]
Laboratoire de Bioimagerie et Pathologies [LBP]

MUTSCHLER, Angela

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Article de revue

Ce document a été publié dans

Langmuir. 2022-06-22

Résumé en anglais

Nanoprecipitation is a facile and efficient approach to the assembly of loaded polymer nanoparticles (NPs) for applications in bioimaging and targeted drug delivery. Their successful use in clinics requires reproducible and scalable synthesis, for which microfluidics appears as an attractive technique. However, in the case of nanoprecipitation, particle formation depends strongly on mixing. Here, we compare 5 different types of microfluidic mixers with respect to the formation and properties of poly(d-l-lactide--glycolide) (PLGA) and poly(methyl methacrylate) NPs loaded with a fluorescent dye salt: a cross-shaped mixer, a multilamination mixer, a split and recombine mixer, two herringbone mixers, and two impact jet mixers. Size and fluorescence properties of the NPs obtained with these mixers are evaluated. All mixers, except the cross-shaped one, yield NPs at least as small and fluorescent as those obtained manually. Notably in the case of impact jet mixers operated at high flow speeds, the size of the NPs could be strongly reduced from >50 nm down to 70%. These results show the importance of precisely controlling the assembly conditions for loaded polymer NPs. The present work further provides guidance for choosing the optimal microfluidic setup for production of nanomaterials for biomedical applications.< Réduire

Mots clés

Nanoprecipitation

Size control

Mots clés en anglais

Microfluidics

Polymer nanoparticles

Fluorescent nanoparticles

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140314

DOI

http://dx.doi.org/10.1021/acs.langmuir.2c00534

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Assembly of Fluorescent Polymer Nanoparticles Using Different Microfluidic Mixers.