CHAMBERLAIN, Jonviea D.; ROUANET, Anais; DUBOIS, Bruno; PASQUIER, Florence; HANON, Olivier; GABELLE, Audrey; CECCALDI, Mathieu; KROLAK-SALMON, Pierre; BEJOT, Yannick; GODEFROY, Olivier; WALLON, David; GENTRIC, Armelle; CHENE, Genevieve; DUFOUIL, Carole

doi:10.1002/alz.12308

CHAMBERLAIN, Jonviea D.
Bordeaux population health [BPH]

ROUANET, Anais

Bordeaux population health [BPH]

DUBOIS, Bruno

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Article de revue

Ce document a été publié dans

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2021-09, vol. 17, n° 9, p. 1415-1421

Résumé en anglais

IntroductionStudies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding.MethodsThis study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness‐death models (IDMs) were used to estimate transition‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry.ResultsThe analytical sample (N = 2258) excluded 65 individuals without follow‐up information. At the end of follow‐up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35‐0.97), with a corresponding E‐value of 2.84 (lower CI = 1.21).DiscussionThis study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.< Réduire

Mots clés en anglais

illness-death model

selection bias

Alzheimer's disease

cancer

dementia

epidemiology

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140236

DOI

http://dx.doi.org/10.1002/alz.12308

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Investigating the association between cancer and the risk of dementia: Results from the Memento cohort

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