Detection of Short DNA Sequences with DNA Nanopores
| dc.rights.license | open | en_US |
| hal.structure.identifier | Centre de Recherche Paul Pascal [CRPP] | |
| dc.contributor.author | YANG, Luyan | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CULLIN, Christophe
ORCID: 0000-0003-4110-4677 IDREF: 85920959 | |
| hal.structure.identifier | Centre de Recherche Paul Pascal [CRPP] | |
| dc.contributor.author | ELEZGARAY, Juan | |
| dc.date.accessioned | 2022-06-13T15:34:50Z | |
| dc.date.available | 2022-06-13T15:34:50Z | |
| dc.date.issued | 2022 | |
| dc.identifier.issn | 1439-4235, 1439-7641 | en_US |
| dc.identifier.other | https://chemistry-europe.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fcphc.202200021&file=cphc202200021-sup-0001-misc_information.pdf | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140198 | |
| dc.description.abstractEn | Several studies suggest strong correlation between different types of cancer and the relative concentration of short circulating RNA sequences (miRNA). Because of short length and low concentration, miRNA detection is not easy. Standard methods such as RT-PCR require both the standard PCR amplification step and a preliminary additional step of reverse transcription. In this paper, we investigate the use of DNA nanopores as a tool to detect short oligonucleotide sequences at the single molecule level. These nanostructures show two different conformations depending on the presence of DNA analogues of miRNA sequences. By monitoring current across a lipid bilayer, we show that this change of conformation translates to different levels of conductance. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | DNA origami | |
| dc.subject.en | nanopore | |
| dc.subject.en | self-assembly | |
| dc.subject.en | droplet interface bilayer | |
| dc.subject.en | microRNA | |
| dc.title.en | Detection of Short DNA Sequences with DNA Nanopores | |
| dc.title.alternative | ChemPhysChem | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/cphc.202200021 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | ChemPhysChem | en_US |
| bordeaux.volume | 23 | en_US |
| bordeaux.hal.laboratories | Centre de Recherche Paul Pascal (CRPP) - UMR 5031 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03776932 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-09-14T08:30:07Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ChemPhysChem&rft.date=2022&rft.volume=23&rft.issue=7&rft.eissn=1439-4235,%201439-7641&rft.issn=1439-4235,%201439-7641&rft.au=YANG,%20Luyan&CULLIN,%20Christophe&ELEZGARAY,%20Juan&rft.genre=article |
