Neuro-Symbolic XAI: Application to Drug Repurposing for Rare Diseases
Langue
EN
Communication dans un congrès avec actes
Ce document a été publié dans
Database Systems for Advanced Applications. DASFAA 2022. Lecture Notes in Computer Science., International Conference on Database Systems for Advanced Applications, 2022-04-11, Virtual. 2022-04-08, vol. 13247, p. 539-543
Résumé en anglais
An emerging challenge in high stakes fields such as healthcare is to build a more transparent artificial intelligence. Among the fields which use AI techniques, is drug development, and more specifically drug repurposing. ...Lire la suite >
An emerging challenge in high stakes fields such as healthcare is to build a more transparent artificial intelligence. Among the fields which use AI techniques, is drug development, and more specifically drug repurposing. DR involves finding a new indication for an existing drug. The hypotheses generated by DR techniques must be validated. Therefore, the mechanism of generation must be understood. In this project, we focus on DR using link prediction algorithms. Link prediction consists of generating hypotheses about the relationships between a known molecule and a given target. More specifically, this PhD project aims at creating methods allowing to make transparent prediction in the context of drug repurposing but also to understand how the organization of data in a knowledge graph changes the quality of predictions.< Réduire
Mots clés en anglais
XAI
Drug repurposing
Knowledge graph
Unités de recherche