Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity
MOREAU, Jean-Francois
Hétérochimie moléculaire et macromoléculaire [HMM]
Composantes innées de la réponse immunitaire et différenciation [CIRID]
Pathologies infectieuses et cancers : aspects biologiques et thérapeutiques [PICABT]
Service de virologie et d'immunologie biologique
Biogéosciences [UMR 6282] [BGS]
Service d'immunologie et d'immunogénétique [Bordeaux]
CHU Bordeaux
Immunology from Concept and Experiments to Translation [ImmunoConcept]
< Réduire
Hétérochimie moléculaire et macromoléculaire [HMM]
Composantes innées de la réponse immunitaire et différenciation [CIRID]
Pathologies infectieuses et cancers : aspects biologiques et thérapeutiques [PICABT]
Service de virologie et d'immunologie biologique
Biogéosciences [UMR 6282] [BGS]
Service d'immunologie et d'immunogénétique [Bordeaux]
CHU Bordeaux
Immunology from Concept and Experiments to Translation [ImmunoConcept]
Langue
EN
Article de revue
Ce document a été publié dans
Journal of Infectious Diseases. 2021-02, vol. 223, n° 4, p. 655-666
Résumé en anglais
Cytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive Vδ2neg γδ T cells are key effectors responding to CMV and ...Lire la suite >
Cytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive Vδ2neg γδ T cells are key effectors responding to CMV and associated with recovery, contrasting with their innatelike circulating counterparts, the Vγ9posVδ2pos T cells that respond to phosphoantigens but not to CMV. A third Vγ9negVδ2pos subgroup with adaptive functions has been described in adults. In the current study, we demonstrate that these Vγ9negVδ2pos T cells are also components of the CMV immune response while presenting with distinct characteristics from Vδ2neg γδ T cells. In a cohort of kidney transplant recipients, CMV seropositivity was the unique clinical parameter associated with Vγ9negVδ2pos T-cell expansion and differentiation. Extensive phenotyping demonstrated their substantial cytotoxic potential and activation during acute CMV primary infection or reinfection. In vitro, Vγ9negVδ2pos T cells responded specifically to CMV-infected cells in a T-cell receptor–dependent manner and through strong interferon γ production. Finally, Vγ9negVδ2pos T cells were the only γδ T-cell subset in which expansion was tightly correlated with the severity of CMV disease. To conclude, our results identify a new player in the immune response against CMV and open interesting clinical perspectives for using Vγ9negVδ2pos T cells as an immune marker for CMV disease severity in immunocompromised patients.< Réduire
Mots clés en anglais
CMV infection
Gamma-delta T cells
Kidney transplant recipients
Unités de recherche