ER-RAFIK, Meriem; FERJI, Khalid; COMBET, Jérôme; SANDRE, Olivier; LECOMMANDOUX, Sebastien; SCHMUTZ, Marc; LE MEINS, Jean-François; MARQUES, Carlos

doi:10.1039/D2SM00179A

ER-RAFIK, Meriem
Institut Charles Sadron [ICS]
Université de Bâle = University of Basel = Basel Universität [Unibas]

FERJI, Khalid
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie Physique Macromoléculaire [LCPM]

COMBET, Jérôme
Institut Charles Sadron [ICS]

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Article de revue

Ce document a été publié dans

Soft Matter. 2022-04-14, vol. 18, n° 17, p. 3318-3322

Résumé en anglais

Health concerns associated with the advent of nanotechnologies have risen sharply when it was found that particles of nanoscopic dimensions reach the cell lumina. Plasma and organelle lipid membranes, which are exposed to both the incoming and the engulfed nanoparticles, are the primary targets of possible disruptions. However, reported adhesion, invagination and embedment of nanoparticles (NPs) do not compromise the membrane integrity, precluding direct bilayer damage as a mechanism for toxicity. Here it is shown that a lipid membrane can be torn by small enough nanoparticles, thus unveiling mechanisms for how lipid membrane can be compromised by tearing from nanoparticles. Surprisingly, visualization by cryo transmission electron microscopy (cryo-TEM) of liposomes exposed to nanoparticles revealed also that liposomal laceration is prevented by particle abundance. Membrane destruction results thus from a subtle particle-membrane interplay that is here elucidated. This brings into a firmer molecular basis the theorized mechanisms of nanoparticle effects on lipid bilayers and paves the way for a better assessment of nanoparticle toxicity.< Réduire

Mots clés en anglais

lipid membranes

nanoparticles

silica particles

cryo-electron microscopy

nano- toxicity

URI

https://oskar-bordeaux.fr/handle/20.500.12278/139996

DOI

http://dx.doi.org/10.1039/D2SM00179A

Project ANR

Cinétique de Translocation de Particules à travers de Bicouches Auto-Assemblées - ANR-12-BS08-0018

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Tear of Lipid Membranes by Nanoparticles