NICOLI, F.; PACIFICO, S.; GALLERANI, E.; MARZOLA, E.; ALBANESE, V.; FINESSI, V.; LLEWELLYN-LACEY, S.; PRICE, D.A.; APPAY, Victor; MARCONI, P.; GUERRINI, R.; CAPUTO, A.; GAVIOLI, R.

doi:10.3390/vaccines9050526

Langue

Article de revue

Ce document a été publié dans

Vaccines. 2021-05-19, vol. 9, n° 5

Résumé en anglais

Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We developed tetrabranched derivatives for this purpose based on a novel peptide welding technology (PWT). PWTs provide molecular scaffolds for the efficient synthesis of ultrapure peptide dendrimers, which allow the delivery of multiple ligands within a single macromolecular structure. Peptide vaccines incorporating T-cell epitopes derived from melanoma and B-cell epitopes derived from human immunodeficiency virus, synthesized using this approach, elicited primary immune responses in vitro and in vivo. Subcutaneous administration of the B-cell epitope-based vaccines also elicited more potent humoral responses than subcutaneous administration of the corresponding peptides alone. Highly immunogenic peptide epitope-based vaccines can therefore be generated quickly and easily using a novel PWT.< Réduire

Mots clés en anglais

Adaptive immune responses

B-cell epitopes

Peptide vaccines

T-cell epitopes

URI

https://oskar-bordeaux.fr/handle/20.500.12278/139976

DOI

http://dx.doi.org/10.3390/vaccines9050526

Unités de recherche

ImmunoConcEpT - UMR 5164

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Use of a novel peptide welding technology platform for the development of B- and T-cell epitope-based vaccines

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche