BESTARD, O.; COUZI, Lionel; CRESPO, M.; KESSARIS, N.; THAUNAT, O.

doi:10.1111/tri.13874

COUZI, Lionel
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

CRESPO, M.

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Article de revue

Ce document a été publié dans

Transplant International. 2021-06, vol. 34, n° 6, p. 1005-1018

Résumé en anglais

Detection of circulating antibodies directed against human leukocyte antigen (HLA) molecules, which corresponds to the current definition of ‘sensitized patient’, has been shown to have a severe impact on both access to transplantation and, if the anti-HLA antibodies are specific to the selected donor, survival of the graft. However, not all donor-specific antibodies (DSA) are equally harmful to the graft and progress in the understanding of humoral memory has led to the conclusion that absence of DSA at transplantation does not rule out the possibility that the patient has a preformed cellular humoral memory against the graft (thereby defining a category of DSA-negative sensitized recipients). Technological progress has led to the generation of new assays that offer unprecedented precision in exploring the different layers (serological and cellular) of alloimmune humoral memory. Based on this recent knowledge, the EuropeaN Guidelines for the mAnagement of Graft rEcipients (ENGAGE) working group to propose an updated definition of sensitization in candidates for solid organ transplantation – one that moves away from the current binary division towards a definition based on homogenous strata with similar humoral risk.< Réduire

Mots clés en anglais

Antibody-mediated rejection

Humoral alloimmune response

Presensitization

URI

https://oskar-bordeaux.fr/handle/20.500.12278/139969

DOI

http://dx.doi.org/10.1111/tri.13874

Unités de recherche

ImmunoConcEpT - UMR 5164

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Stratifying the humoral risk of candidates to a solid organ transplantation: a proposal of the ENGAGE working group

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Résumé en anglais

Mots clés en anglais

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Unités de recherche