GIRAUD, Julie; SALEH, Maya

doi:10.3390/cancers13174342

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

SALEH, Maya

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Cancers. 2021-08-27, vol. 13, n° 17

Résumé en anglais

Hepatocellular carcinoma (HCC) is a classical inflammation-promoted cancer that occurs in a setting of liver diseases, including nonalcoholic fatty liver disease (NAFLD) or alcoholic liver disease (ALD). These pathologies share key characteristics, notably intestinal dysbiosis, increased intestinal permeability and an imbalance in bile acids, choline, fatty acids and ethanol metabolites. Translocation of microbial-and danger-associated molecular patterns (MAMPs and DAMPs) from the gut to the liver elicits profound chronic inflammation, leading to severe hepatic injury and eventually HCC progression. In this review, we first describe how the gut and the liver communicate and discuss mechanisms by which the intestinal microbiota elicit hepatic inflammation and HCC. We focus on the role of microbial products, e.g., MAMPs, host inflammatory effectors and host�microbiome-derived metabolites in tumor-promoting mechanisms, including cell death and senescence. Last, we explore the potential of harnessing the microbiota to treat liver diseases and HCC.< Réduire

Mots clés en anglais

Alcoholic liver disease

Cirrhosis

Gut-liver axis

Inflammation

Innate immunity

Metabolism

Microbiome

Obesity

URI

https://oskar-bordeaux.fr/handle/20.500.12278/139939

DOI

http://dx.doi.org/10.3390/cancers13174342

Unités de recherche

ImmunoConcEpT - UMR 5164

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Host-microbiota interactions in liver inflammation and cancer

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Résumé en anglais

Mots clés en anglais

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Unités de recherche