BOUARAB, Chloe; ROULLOT-LACARRIERE, Valerie; VALLEE, Monique; LEROUX, Anne; GUETTE, Christelle; MENNESSON, Marie; MARIGHETTO, Aline; DESMEDT, Aline; PIAZZA, Pier Vincenzo; REVEST, Jean-Michel

doi:10.1038/s41380-021-01024-1

BOUARAB, Chloe
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

ROULLOT-LACARRIERE, Valerie
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

VALLEE, Monique

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

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Molecular Psychiatry. 2021-09, vol. 26, n° 9, p. 4968-4981

Résumé en anglais

Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/139909

DOI

http://dx.doi.org/10.1038/s41380-021-01024-1

Project ANR

Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Altérations neurobiologiques systémiques et moléculaires de la mémoire de type post-traumatique - ANR-14-CE13-0026

Unités de recherche

Neurocentre Magendie - U1215

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PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory

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Résumé en anglais

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DOI

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