ROUMES, Hélène; SANCHEZ, Stéphane; BENKHALED, Imad; FERNANDEZ, Valentin; GOUDENECHE, Pierre; PERRIN, Flavie; PELLERIN, Luc; GUILLARD, Jérôme; BOUZIER-SORE, Anne-Karine

doi:10.3390/nu14040773

ROUMES, Hélène
Centre de résonance magnétique des systèmes biologiques [CRMSB]

SANCHEZ, Stéphane
Centre de résonance magnétique des systèmes biologiques [CRMSB]

BENKHALED, Imad
Centre de résonance magnétique des systèmes biologiques [CRMSB]

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Article de revue

Ce document a été publié dans

Nutrients. 2022-02-12, vol. 14, n° 4

Résumé en anglais

Polyphenols are natural compounds with promising prophylactic and therapeutic applications. However, their methods of extraction, using organic solvents, may prove to be unsuitable for daily consumption or for certain medical indications. Here, we describe the neuroprotective effects of grape polyphenols extracted in an eco-sustainable manner in a rat model of neonatal hypoxia-ischemia (NHI). Polyphenols (resveratrol, pterostilben and viniferin) were obtained using a subcritical water extraction technology to avoid organic solvents and heavy metals associated with chemical synthesis processes. A resveratrol or a polyphenol cocktail were administered to pregnant females at a nutritional dose and different time windows, prior to induction of NHI in pups. Reduced brain edema and lesion volumes were observed in rat pups whose mothers were supplemented with polyphenols. Moreover, the preservation of motor and cognitive functions (including learning and memory) was evidenced in the same animals. Our results pave the way to the use of polyphenols to prevent brain lesions and their associated deficits that follow NHI, which is a major cause of neonatal death and disabilities.< Réduire

Mots clés en anglais

neonatal hypoxia-ischemia

maternal supplementation

neuroprotection

resveratrol

grape-polyphenol

MRI

behavior

URI

https://oskar-bordeaux.fr/handle/20.500.12278/139891

DOI

http://dx.doi.org/10.3390/nu14040773

Project ANR

Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003

Unités de recherche

Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536

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Neuroprotective Effect of Eco-Sustainably Extracted Grape Polyphenols in Neonatal Hypoxia-Ischemia.